In vivo plaque characterization using intravascular ultrasound-virtual histology in a porcine model of complex coronary lesions

Juan F. Granada, David Wallace-Bradley, Htut K. Win, Carlos L. Alviar, Angela Builes, Eli I. Lev, Roberto Barrios, Daryl G. Schulz, Albert E. Raizner, Greg L. Kaluza

Research output: Contribution to journalArticle

90 Scopus citations

Abstract

OBJECTIVE - To determine the accuracy of detection of different tissue types of intravascular ultrasound-virtual histology (IVUS-VH) in a porcine model of complex coronary lesions. METHODS AND RESULTS - Coronary lesions were induced by injecting liposomes containing human oxidized low-density lipoprotein into the adventitia of the arteries. IVUS-VH imaging was performed in vivo at 8.2±1.6 weeks after injection. A total of 60 vascular lesions were analyzed and compared with their correspondent IVUS-VH images. Correlation analysis was performed using linear regression models. Compared with histology, IVUS-VH correctly identified the presence of fibrous, fibro-fatty, and necrotic tissue in 58.33%, 38.33%, and 38.33% of lesions, respectively. The sensitivity of IVUS-VH for the detection of fibrous, fibro-fatty, and necrotic core tissue was 76.1%, 46%, and 41.1% respectively. A linear regression analysis performed for each individual plaque component did not show strong correlation that would allow significant prediction of individual values. CONCLUSIONS - In a porcine model of complex coronary lesions, IVUS-VH was not accurate in detecting the relative amount of specific plaque components within each individual corresponding histological specimen.

Original languageEnglish (US)
Pages (from-to)387-393
Number of pages7
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume27
Issue number2
DOIs
StatePublished - Feb 2007

Keywords

  • Animal model
  • Intravascular ultrasound
  • Vulnerable plaque

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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