In vivo imaging of radiopaque resorbable inferior vena cava filter infused with gold nanoparticles

Li Tian, Patrick Lee, Burapol Singhana, Aaron Chen, Yang Qiao, Linfeng Lu, Jonathan Martinez, Ennio Tasciotti, Megan C. Jacobsen, Adam Melancon, Mark McArthur, Mitch Eggers, Steven Huang, Marites P. Melancon

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

Radiopaque resorbable inferior vena cava filter (IVCF) were developed to offer a less expensive alternative to assessing filter integrity in preventing pulmonary embolism for the recommended prophylactic period and then simply vanishes without intervention. In this study, we determined the efficacy of gold nanoparticle (AuNP)-infused poly-p-dioxanone (PPDO) as an IVCF in a swine model. Infusion into PPDO loaded 1.14±0.08 % AuNP by weight as determined by elemental analysis. The infusion did not alter PPDO's mechanical strength nor crystallinity (Kruskalâ'Wallis one-way ANOVA, p<0.05). There was no cytotoxicity observed (one-way ANOVA, p<0.05) when tested against RF24 and MRC5 cells. Gold content in PPDO was maintained at ∼2000 ppm during the 6-week incubation in PBS at 37oC. As a proof-of-concept, two pigs were deployed with IVCF, one with AuNP-PPDO and the other without coating. Results show that the stent ring of AuNP-PPDO was highly visible even in the presence of iodine-based contrast agent and after clot introduction, but not of the uncoated IVCF. Autopsy at two weeks post-implantation showed AuNP-PPDO filter was endothelialized onto the IVC wall, and no sign of filter migration was observed. The induced clot was also still trapped within the AuNP-PPDO IVCF. As a conclusion, we successfully fabricated AuNP-infused PPDO IVCF that is radiopaque, has robust mechanical strength, biocompatible, and can be imaged effectively in vivo. This suggests the efficacy of this novel, radiopaque, absorbable IVCF for monitoring its position and integrity over time, thus increasing the safety and efficacy of deep vein thrombosis treatment.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2018
Subtitle of host publicationImage-Guided Procedures, Robotic Interventions, and Modeling
EditorsBaowei Fei, Robert J. Webster
PublisherSPIE
Volume10576
ISBN (Electronic)9781510616417
DOIs
StatePublished - 2018
EventMedical Imaging 2018: Image-Guided Procedures, Robotic Interventions, and Modeling - Houston, United States
Duration: Feb 12 2018Feb 15 2018

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10576
ISSN (Print)1605-7422

Conference

ConferenceMedical Imaging 2018: Image-Guided Procedures, Robotic Interventions, and Modeling
CountryUnited States
CityHouston
Period2/12/182/15/18

Keywords

  • Gold nanoparticles (AuNP)
  • Inferior vena cava filter (IVCF)
  • Poly-p-dioxanone (PPDO)
  • Pulmonary embolism
  • X-ray and computed tomography (CT)

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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