In-vivo imaging of carotid plaque neoangiogenesis with contrast-enhanced harmonic ultrasound

Theodore G. Papaioannou, Manolis Vavuranakis, Aristides Androulakis, George Lazaros, Ioannis Kakadiaris, Ioannis Vlaseros, Morteza Naghavi, Ioannis Kallikazaros, Christodoulos Stefanadis

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


We describe a case where a mild carotid atherosclerotic plaque was assessed by contrast enhanced harmonic ultrasonography and image analysis. Quantitative indices of plaque echogenicity were determined prior and after the injection of microbubbles. Changes in plaque echogenicity were detected possibly due to the flow of microbubbles through vasa vasorum within the plaque and at the plaque base at the adventitial level. Future histological studies remain to be done to link the presence and the extent of plaque and adventitial neovascularization with the visual and quantitative findings derived by contrast enhanced harmonic ultrasound and image analysis.

Original languageEnglish (US)
Pages (from-to)e110-e112
JournalInternational Journal of Cardiology
Issue number3
StatePublished - May 29 2009


  • Harmonic ultrasound
  • Microbubbles
  • Neoangiogenesis
  • Vasa vasorum
  • Vulnerable plaque

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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