In-vivo imaging of carotid plaque neoangiogenesis with contrast-enhanced harmonic ultrasound

Theodore G. Papaioannou; Manolis Vavuranakis; Aristides Androulakis; George Lazaros; Ioannis Kakadiaris; Ioannis Vlaseros; Morteza Naghavi; Ioannis Kallikazaros; Christodoulos Stefanadis

doi:10.1016/j.ijcard.2008.01.020

In-vivo imaging of carotid plaque neoangiogenesis with contrast-enhanced harmonic ultrasound

Theodore G. Papaioannou, Manolis Vavuranakis, Aristides Androulakis, George Lazaros, Ioannis Kakadiaris, Ioannis Vlaseros, Morteza Naghavi, Ioannis Kallikazaros, Christodoulos Stefanadis

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

We describe a case where a mild carotid atherosclerotic plaque was assessed by contrast enhanced harmonic ultrasonography and image analysis. Quantitative indices of plaque echogenicity were determined prior and after the injection of microbubbles. Changes in plaque echogenicity were detected possibly due to the flow of microbubbles through vasa vasorum within the plaque and at the plaque base at the adventitial level. Future histological studies remain to be done to link the presence and the extent of plaque and adventitial neovascularization with the visual and quantitative findings derived by contrast enhanced harmonic ultrasound and image analysis.

Original language	English (US)
Pages (from-to)	e110-e112
Journal	International Journal of Cardiology
Volume	134
Issue number	3
DOIs	https://doi.org/10.1016/j.ijcard.2008.01.020
State	Published - May 29 2009

Keywords

Harmonic ultrasound
Microbubbles
Neoangiogenesis
Vasa vasorum
Vulnerable plaque

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Access to Document

10.1016/j.ijcard.2008.01.020

Cite this

@article{6178232946ea437fa11bf84f63cf907e,

title = "In-vivo imaging of carotid plaque neoangiogenesis with contrast-enhanced harmonic ultrasound",

abstract = "We describe a case where a mild carotid atherosclerotic plaque was assessed by contrast enhanced harmonic ultrasonography and image analysis. Quantitative indices of plaque echogenicity were determined prior and after the injection of microbubbles. Changes in plaque echogenicity were detected possibly due to the flow of microbubbles through vasa vasorum within the plaque and at the plaque base at the adventitial level. Future histological studies remain to be done to link the presence and the extent of plaque and adventitial neovascularization with the visual and quantitative findings derived by contrast enhanced harmonic ultrasound and image analysis.",

keywords = "Harmonic ultrasound, Microbubbles, Neoangiogenesis, Vasa vasorum, Vulnerable plaque",

author = "Papaioannou, {Theodore G.} and Manolis Vavuranakis and Aristides Androulakis and George Lazaros and Ioannis Kakadiaris and Ioannis Vlaseros and Morteza Naghavi and Ioannis Kallikazaros and Christodoulos Stefanadis",

year = "2009",

month = may,

day = "29",

doi = "10.1016/j.ijcard.2008.01.020",

language = "English (US)",

volume = "134",

pages = "e110--e112",

journal = "International Journal of Cardiology",

issn = "0167-5273",

publisher = "Elsevier Ireland Ltd",

number = "3",

}

TY - JOUR

T1 - In-vivo imaging of carotid plaque neoangiogenesis with contrast-enhanced harmonic ultrasound

AU - Papaioannou, Theodore G.

AU - Vavuranakis, Manolis

AU - Androulakis, Aristides

AU - Lazaros, George

AU - Kakadiaris, Ioannis

AU - Vlaseros, Ioannis

AU - Naghavi, Morteza

AU - Kallikazaros, Ioannis

AU - Stefanadis, Christodoulos

PY - 2009/5/29

Y1 - 2009/5/29

N2 - We describe a case where a mild carotid atherosclerotic plaque was assessed by contrast enhanced harmonic ultrasonography and image analysis. Quantitative indices of plaque echogenicity were determined prior and after the injection of microbubbles. Changes in plaque echogenicity were detected possibly due to the flow of microbubbles through vasa vasorum within the plaque and at the plaque base at the adventitial level. Future histological studies remain to be done to link the presence and the extent of plaque and adventitial neovascularization with the visual and quantitative findings derived by contrast enhanced harmonic ultrasound and image analysis.

AB - We describe a case where a mild carotid atherosclerotic plaque was assessed by contrast enhanced harmonic ultrasonography and image analysis. Quantitative indices of plaque echogenicity were determined prior and after the injection of microbubbles. Changes in plaque echogenicity were detected possibly due to the flow of microbubbles through vasa vasorum within the plaque and at the plaque base at the adventitial level. Future histological studies remain to be done to link the presence and the extent of plaque and adventitial neovascularization with the visual and quantitative findings derived by contrast enhanced harmonic ultrasound and image analysis.

KW - Harmonic ultrasound

KW - Microbubbles

KW - Neoangiogenesis

KW - Vasa vasorum

KW - Vulnerable plaque

UR - http://www.scopus.com/inward/record.url?scp=67349267851&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67349267851&partnerID=8YFLogxK

U2 - 10.1016/j.ijcard.2008.01.020

DO - 10.1016/j.ijcard.2008.01.020

M3 - Article

C2 - 18495267

AN - SCOPUS:67349267851

VL - 134

SP - e110-e112

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

IS - 3

ER -

In-vivo imaging of carotid plaque neoangiogenesis with contrast-enhanced harmonic ultrasound

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this