In-vivo imaging of carotid plaque neoangiogenesis with contrast-enhanced harmonic ultrasound

Theodore G. Papaioannou; Manolis Vavuranakis; Aristides Androulakis; George Lazaros; Ioannis Kakadiaris; Ioannis Vlaseros; Morteza Naghavi; Ioannis Kallikazaros; Christodoulos Stefanadis

doi:10.1016/j.ijcard.2008.01.020

In-vivo imaging of carotid plaque neoangiogenesis with contrast-enhanced harmonic ultrasound

Theodore G. Papaioannou, Manolis Vavuranakis, Aristides Androulakis, George Lazaros, Ioannis Kakadiaris, Ioannis Vlaseros, Morteza Naghavi, Ioannis Kallikazaros, Christodoulos Stefanadis

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

We describe a case where a mild carotid atherosclerotic plaque was assessed by contrast enhanced harmonic ultrasonography and image analysis. Quantitative indices of plaque echogenicity were determined prior and after the injection of microbubbles. Changes in plaque echogenicity were detected possibly due to the flow of microbubbles through vasa vasorum within the plaque and at the plaque base at the adventitial level. Future histological studies remain to be done to link the presence and the extent of plaque and adventitial neovascularization with the visual and quantitative findings derived by contrast enhanced harmonic ultrasound and image analysis.

Original language	English (US)
Pages (from-to)	e110-e112
Journal	International Journal of Cardiology
Volume	134
Issue number	3
DOIs	https://doi.org/10.1016/j.ijcard.2008.01.020
State	Published - May 29 2009

Keywords

Harmonic ultrasound
Microbubbles
Neoangiogenesis
Vasa vasorum
Vulnerable plaque

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.ijcard.2008.01.020

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title = "In-vivo imaging of carotid plaque neoangiogenesis with contrast-enhanced harmonic ultrasound",

abstract = "We describe a case where a mild carotid atherosclerotic plaque was assessed by contrast enhanced harmonic ultrasonography and image analysis. Quantitative indices of plaque echogenicity were determined prior and after the injection of microbubbles. Changes in plaque echogenicity were detected possibly due to the flow of microbubbles through vasa vasorum within the plaque and at the plaque base at the adventitial level. Future histological studies remain to be done to link the presence and the extent of plaque and adventitial neovascularization with the visual and quantitative findings derived by contrast enhanced harmonic ultrasound and image analysis.",

keywords = "Harmonic ultrasound, Microbubbles, Neoangiogenesis, Vasa vasorum, Vulnerable plaque",

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AU - Papaioannou, Theodore G.

AU - Vavuranakis, Manolis

AU - Androulakis, Aristides

AU - Lazaros, George

AU - Kakadiaris, Ioannis

AU - Vlaseros, Ioannis

AU - Naghavi, Morteza

AU - Kallikazaros, Ioannis

AU - Stefanadis, Christodoulos

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Y1 - 2009/5/29

N2 - We describe a case where a mild carotid atherosclerotic plaque was assessed by contrast enhanced harmonic ultrasonography and image analysis. Quantitative indices of plaque echogenicity were determined prior and after the injection of microbubbles. Changes in plaque echogenicity were detected possibly due to the flow of microbubbles through vasa vasorum within the plaque and at the plaque base at the adventitial level. Future histological studies remain to be done to link the presence and the extent of plaque and adventitial neovascularization with the visual and quantitative findings derived by contrast enhanced harmonic ultrasound and image analysis.

AB - We describe a case where a mild carotid atherosclerotic plaque was assessed by contrast enhanced harmonic ultrasonography and image analysis. Quantitative indices of plaque echogenicity were determined prior and after the injection of microbubbles. Changes in plaque echogenicity were detected possibly due to the flow of microbubbles through vasa vasorum within the plaque and at the plaque base at the adventitial level. Future histological studies remain to be done to link the presence and the extent of plaque and adventitial neovascularization with the visual and quantitative findings derived by contrast enhanced harmonic ultrasound and image analysis.

KW - Harmonic ultrasound

KW - Microbubbles

KW - Neoangiogenesis

KW - Vasa vasorum

KW - Vulnerable plaque

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In-vivo imaging of carotid plaque neoangiogenesis with contrast-enhanced harmonic ultrasound

Abstract

Keywords

ASJC Scopus subject areas

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