In Vivo Assessment of Cardiac Radiofrequency Ablation in a Large-Animal Model Using Photoacoustic-Ultrasound Imaging

Nilesh Mathuria; Krithik Vishwanath; Blake C. Fallon; Antonio Martino; Giorgio Brero; Richard C. Willson; Miguel Valderrabano; Carly S. Filgueira; Richard R. Bouchard

doi:10.1016/j.jacep.2025.02.031

In Vivo Assessment of Cardiac Radiofrequency Ablation in a Large-Animal Model Using Photoacoustic-Ultrasound Imaging

Nilesh Mathuria, Krithik Vishwanath, Blake C. Fallon, Antonio Martino, Giorgio Brero, Richard C. Willson, Miguel Valderrabano, Carly S. Filgueira, Richard R. Bouchard

Research output: Contribution to journal › Review article › peer-review

Abstract

Despite advancements in catheter technology, intraoperative assessment of radiofrequency ablation (RFA) lesions remains elusive. Prior ex vivo data suggest photoacoustic imaging (PAI) can provide RFA lesion characteristics, but in vivo data are lacking. PAI involves delivering near-infrared light to tissue, leading to transient acoustic waves that can be detected by clinically available ultrasound transducers, providing optically based tissue characterization at depth. Three epicardial RFA lesions were delivered in an open-chest porcine model. In vivo PAI-based measurements of RFA lesion dimensions matched (<0.7-mm error) gross pathologic assessment, yielding in vivo feasibility data of PAI to provide intraoperative RFA lesion dimensions.

Original language	English (US)
Pages (from-to)	1024-1029
Number of pages	6
Journal	JACC: Clinical Electrophysiology
Volume	11
Issue number	5
DOIs	https://doi.org/10.1016/j.jacep.2025.02.031
State	Published - May 2025

Keywords

catheter ablation
photoacoustic imaging
radiofrequency ablation
ultrasound
ventricular tachycardia

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Physiology (medical)

Access to Document

10.1016/j.jacep.2025.02.031

Cite this

@article{30b40b9ebd98453da6ede70216dd4fa9,

title = "In Vivo Assessment of Cardiac Radiofrequency Ablation in a Large-Animal Model Using Photoacoustic-Ultrasound Imaging",

abstract = "Despite advancements in catheter technology, intraoperative assessment of radiofrequency ablation (RFA) lesions remains elusive. Prior ex vivo data suggest photoacoustic imaging (PAI) can provide RFA lesion characteristics, but in vivo data are lacking. PAI involves delivering near-infrared light to tissue, leading to transient acoustic waves that can be detected by clinically available ultrasound transducers, providing optically based tissue characterization at depth. Three epicardial RFA lesions were delivered in an open-chest porcine model. In vivo PAI-based measurements of RFA lesion dimensions matched (<0.7-mm error) gross pathologic assessment, yielding in vivo feasibility data of PAI to provide intraoperative RFA lesion dimensions.",

keywords = "catheter ablation, photoacoustic imaging, radiofrequency ablation, ultrasound, ventricular tachycardia",

author = "Nilesh Mathuria and Krithik Vishwanath and Fallon, {Blake C.} and Antonio Martino and Giorgio Brero and Willson, {Richard C.} and Miguel Valderrabano and Filgueira, {Carly S.} and Bouchard, {Richard R.}",

note = "Publisher Copyright: {\textcopyright} 2025 The Authors",

year = "2025",

month = may,

doi = "10.1016/j.jacep.2025.02.031",

language = "English (US)",

volume = "11",

pages = "1024--1029",

journal = "JACC: Clinical Electrophysiology",

issn = "2405-500X",

publisher = "Elsevier",

number = "5",

}

TY - JOUR

T1 - In Vivo Assessment of Cardiac Radiofrequency Ablation in a Large-Animal Model Using Photoacoustic-Ultrasound Imaging

AU - Mathuria, Nilesh

AU - Vishwanath, Krithik

AU - Fallon, Blake C.

AU - Martino, Antonio

AU - Brero, Giorgio

AU - Willson, Richard C.

AU - Valderrabano, Miguel

AU - Filgueira, Carly S.

AU - Bouchard, Richard R.

PY - 2025/5

Y1 - 2025/5

N2 - Despite advancements in catheter technology, intraoperative assessment of radiofrequency ablation (RFA) lesions remains elusive. Prior ex vivo data suggest photoacoustic imaging (PAI) can provide RFA lesion characteristics, but in vivo data are lacking. PAI involves delivering near-infrared light to tissue, leading to transient acoustic waves that can be detected by clinically available ultrasound transducers, providing optically based tissue characterization at depth. Three epicardial RFA lesions were delivered in an open-chest porcine model. In vivo PAI-based measurements of RFA lesion dimensions matched (<0.7-mm error) gross pathologic assessment, yielding in vivo feasibility data of PAI to provide intraoperative RFA lesion dimensions.

AB - Despite advancements in catheter technology, intraoperative assessment of radiofrequency ablation (RFA) lesions remains elusive. Prior ex vivo data suggest photoacoustic imaging (PAI) can provide RFA lesion characteristics, but in vivo data are lacking. PAI involves delivering near-infrared light to tissue, leading to transient acoustic waves that can be detected by clinically available ultrasound transducers, providing optically based tissue characterization at depth. Three epicardial RFA lesions were delivered in an open-chest porcine model. In vivo PAI-based measurements of RFA lesion dimensions matched (<0.7-mm error) gross pathologic assessment, yielding in vivo feasibility data of PAI to provide intraoperative RFA lesion dimensions.

KW - catheter ablation

KW - photoacoustic imaging

KW - radiofrequency ablation

KW - ultrasound

KW - ventricular tachycardia

UR - http://www.scopus.com/inward/record.url?scp=105003926340&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=105003926340&partnerID=8YFLogxK

U2 - 10.1016/j.jacep.2025.02.031

DO - 10.1016/j.jacep.2025.02.031

M3 - Review article

C2 - 40310313

AN - SCOPUS:105003926340

SN - 2405-500X

VL - 11

SP - 1024

EP - 1029

JO - JACC: Clinical Electrophysiology

JF - JACC: Clinical Electrophysiology

IS - 5

ER -

In Vivo Assessment of Cardiac Radiofrequency Ablation in a Large-Animal Model Using Photoacoustic-Ultrasound Imaging

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this