In vitro killing of community-associated methicillin-resistant Staphylococcus aureus with drug combinations

Samuel Shelburne; Daniel M. Musher; Kristina Hulten; Heather Ceasar; Michael Y. Lu; Imran Bhaila; Richard J. Hamill

doi:10.1128/AAC.48.10.4016-4019.2004

In vitro killing of community-associated methicillin-resistant Staphylococcus aureus with drug combinations

Samuel Shelburne, Daniel M. Musher, Kristina Hulten, Heather Ceasar, Michael Y. Lu, Imran Bhaila, Richard J. Hamill

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57 Scopus citations

Abstract

This study employs time-kill techniques to examine the most common drug combinations used in the therapy of methicillin-resistant Staphylococcus aureus (MRSA) infections, vancomycin plus either gentamicin or rifampin. Community-associated MRSA were more likely to be synergistically inhibited by combinations of vancomycin and gentamicin versus vancomycin alone compared to inhibition associated with hospital-acquired strains.

Original language	English (US)
Pages (from-to)	4016-4019
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	48
Issue number	10
DOIs	https://doi.org/10.1128/AAC.48.10.4016-4019.2004
State	Published - Oct 2004

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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abstract = "This study employs time-kill techniques to examine the most common drug combinations used in the therapy of methicillin-resistant Staphylococcus aureus (MRSA) infections, vancomycin plus either gentamicin or rifampin. Community-associated MRSA were more likely to be synergistically inhibited by combinations of vancomycin and gentamicin versus vancomycin alone compared to inhibition associated with hospital-acquired strains.",

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AU - Lu, Michael Y.

AU - Bhaila, Imran

AU - Hamill, Richard J.

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AB - This study employs time-kill techniques to examine the most common drug combinations used in the therapy of methicillin-resistant Staphylococcus aureus (MRSA) infections, vancomycin plus either gentamicin or rifampin. Community-associated MRSA were more likely to be synergistically inhibited by combinations of vancomycin and gentamicin versus vancomycin alone compared to inhibition associated with hospital-acquired strains.

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In vitro killing of community-associated methicillin-resistant Staphylococcus aureus with drug combinations

Abstract

ASJC Scopus subject areas

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