In vitro killing of community-associated methicillin-resistant Staphylococcus aureus with drug combinations

Samuel Shelburne, Daniel M. Musher, Kristina Hulten, Heather Ceasar, Michael Y. Lu, Imran Bhaila, Richard J. Hamill

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

This study employs time-kill techniques to examine the most common drug combinations used in the therapy of methicillin-resistant Staphylococcus aureus (MRSA) infections, vancomycin plus either gentamicin or rifampin. Community-associated MRSA were more likely to be synergistically inhibited by combinations of vancomycin and gentamicin versus vancomycin alone compared to inhibition associated with hospital-acquired strains.

Original languageEnglish (US)
Pages (from-to)4016-4019
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume48
Issue number10
DOIs
StatePublished - Oct 2004

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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