In vitro killing of community-associated methicillin-resistant Staphylococcus aureus with drug combinations

Samuel Shelburne, Daniel M. Musher, Kristina Hulten, Heather Ceasar, Michael Y. Lu, Imran Bhaila, Richard J. Hamill

    Research output: Contribution to journalArticlepeer-review

    57 Scopus citations

    Abstract

    This study employs time-kill techniques to examine the most common drug combinations used in the therapy of methicillin-resistant Staphylococcus aureus (MRSA) infections, vancomycin plus either gentamicin or rifampin. Community-associated MRSA were more likely to be synergistically inhibited by combinations of vancomycin and gentamicin versus vancomycin alone compared to inhibition associated with hospital-acquired strains.

    Original languageEnglish (US)
    Pages (from-to)4016-4019
    Number of pages4
    JournalAntimicrobial Agents and Chemotherapy
    Volume48
    Issue number10
    DOIs
    StatePublished - Oct 2004

    ASJC Scopus subject areas

    • Pharmacology
    • Pharmacology (medical)
    • Infectious Diseases

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