In-vitro evaluation of sensors and amplifiers to measure left ventricular pressure in mice

Craig J. Hartley, Anilkumar K. Reddy, George Taffet

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

Mice are becoming more common as research models, and several companies now manufacture sensors and instrumentation to measure left ventricular (LV) pressure and volume in mice. It is often assumed that pressure is easier to measure than volume, and that all sensors perform similarly, but there are differences. We measured in-vitro the frequency and step responses, immersion response, stability, accuracy, linearity, and sensitivity to lateral or bending force of several solid-state sensors and amplifiers commonly used in mice. We tested 4 microsensors each from Millar, Scisense, and RADI, and also fluidfilled catheters. All solid-state sensors were stable with drifts of <1 mmHg/hr, had flat frequency response to >1 kHz, and were accurate and linear to within +/-2 mmHg from 0-300 mmHg. The frequency response of the fluid-filled catheter was down by 50% at 30 Hz. The amplifiers from Millar, Scisense, and RADI, had time delays of 0.2, 3.2 and 10.6 ms respectively. The Millar and RADI sensors were unresponsive to lateral forces, but the Scisense catheters had sensitivities as high as 5.3 mmHg/g. There are significant differences in solid state pressure sensors and amplifiers which could generate offsets, time delays, and distortions which could go unrecognized in-vivo.

Original languageEnglish (US)
Title of host publicationProceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages965-968
Number of pages4
ISBN (Print)9781424418152
DOIs
StatePublished - 2008
Event30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - Vancouver, BC, Canada
Duration: Aug 20 2008Aug 25 2008

Publication series

NameProceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology"

Other

Other30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
CountryCanada
CityVancouver, BC
Period8/20/088/25/08

Keywords

  • Blood pressure
  • Fidelity
  • Frequency response

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

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