Abstract
Similarities between a unicellular eukaryotic organism Tetrahymena and human cells as well as the ease in management of Tetrahymena cultures stimulated us to investigate this organism as a model for a rapid in vitro test for drugs from the NSAIDs family that could allow for a cellular assay to predict drug blood therapeutic levels. For this purpose, we quantified, by image analysis, changes in Tetrahymena thermophila (TT) cell area as a function of NSAID concentration, and found a correlation with drug effective plasma levels in humans.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 163-167 |
| Number of pages | 5 |
| Journal | Journal of Drug Delivery Science and Technology |
| Volume | 17 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2007 |
Keywords
- Anti-inflammatory
- Effective plasma concentration
- In vitro test
- NSAIDs
- Tetrahymena
ASJC Scopus subject areas
- Pharmaceutical Science
Fingerprint
Dive into the research topics of 'In vitro estimation of effective NSAIDs plasma concentrations in humans by measuring morphometric changes in Tetrahymena'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS