In vitro estimation of effective NSAIDs plasma concentrations in humans by measuring morphometric changes in Tetrahymena

E. Touitou; B. Godin; H. Klein; A. Ron

doi:10.1016/S1773-2247(07)50030-4

In vitro estimation of effective NSAIDs plasma concentrations in humans by measuring morphometric changes in Tetrahymena

E. Touitou, B. Godin, H. Klein, A. Ron

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Similarities between a unicellular eukaryotic organism Tetrahymena and human cells as well as the ease in management of Tetrahymena cultures stimulated us to investigate this organism as a model for a rapid in vitro test for drugs from the NSAIDs family that could allow for a cellular assay to predict drug blood therapeutic levels. For this purpose, we quantified, by image analysis, changes in Tetrahymena thermophila (TT) cell area as a function of NSAID concentration, and found a correlation with drug effective plasma levels in humans.

Original language	English (US)
Pages (from-to)	163-167
Number of pages	5
Journal	Journal of Drug Delivery Science and Technology
Volume	17
Issue number	3
DOIs	https://doi.org/10.1016/S1773-2247(07)50030-4
State	Published - 2007

Keywords

Anti-inflammatory
Effective plasma concentration
In vitro test
NSAIDs
Tetrahymena

ASJC Scopus subject areas

Pharmaceutical Science

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10.1016/S1773-2247(07)50030-4

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abstract = "Similarities between a unicellular eukaryotic organism Tetrahymena and human cells as well as the ease in management of Tetrahymena cultures stimulated us to investigate this organism as a model for a rapid in vitro test for drugs from the NSAIDs family that could allow for a cellular assay to predict drug blood therapeutic levels. For this purpose, we quantified, by image analysis, changes in Tetrahymena thermophila (TT) cell area as a function of NSAID concentration, and found a correlation with drug effective plasma levels in humans.",

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AU - Ron, A.

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AB - Similarities between a unicellular eukaryotic organism Tetrahymena and human cells as well as the ease in management of Tetrahymena cultures stimulated us to investigate this organism as a model for a rapid in vitro test for drugs from the NSAIDs family that could allow for a cellular assay to predict drug blood therapeutic levels. For this purpose, we quantified, by image analysis, changes in Tetrahymena thermophila (TT) cell area as a function of NSAID concentration, and found a correlation with drug effective plasma levels in humans.

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In vitro estimation of effective NSAIDs plasma concentrations in humans by measuring morphometric changes in Tetrahymena

Abstract

Keywords

ASJC Scopus subject areas

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