In vitro estimation of effective NSAIDs plasma concentrations in humans by measuring morphometric changes in Tetrahymena

E. Touitou, B. Godin, H. Klein, A. Ron

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Similarities between a unicellular eukaryotic organism Tetrahymena and human cells as well as the ease in management of Tetrahymena cultures stimulated us to investigate this organism as a model for a rapid in vitro test for drugs from the NSAIDs family that could allow for a cellular assay to predict drug blood therapeutic levels. For this purpose, we quantified, by image analysis, changes in Tetrahymena thermophila (TT) cell area as a function of NSAID concentration, and found a correlation with drug effective plasma levels in humans.

Original languageEnglish (US)
Pages (from-to)163-167
Number of pages5
JournalJournal of Drug Delivery Science and Technology
Volume17
Issue number3
DOIs
StatePublished - 2007

Keywords

  • Anti-inflammatory
  • Effective plasma concentration
  • In vitro test
  • NSAIDs
  • Tetrahymena

ASJC Scopus subject areas

  • Pharmaceutical Science

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