In vitro antifungal activities of amphotericin B and liposome-encapsulated amphotericin B

R. L. Hopfer, K. Mills, R. Mehta, G. Lopez-Berestein, V. Fainstein, R. L. Juliano

Research output: Contribution to journalArticle

76 Scopus citations

Abstract

The in vitro activities of liposome-encapsulated amphotericin B and free amphotericin B against Candida albicans 336 were comparable. Amphotericin B concentrations 12-fold and greater than 50-fold higher were required to kill the same organism when cholesterol and ergosterol were incorporated into the liposomes. The addition of cholesterol to liposomes caused a significant increase in the minimal fungicidal concentration of amphotericin B in 7 of 19 other yeast strains tested, whereas ergosterol caused an increase in 18 of the 19 strains.

Original languageEnglish (US)
Pages (from-to)387-389
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume25
Issue number3
DOIs
StatePublished - 1984

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'In vitro antifungal activities of amphotericin B and liposome-encapsulated amphotericin B'. Together they form a unique fingerprint.

Cite this