Abstract
Gold nanorods excited at 830 nm on a far-field laser-scanning microscope produced strong two-photon luminescence (TPL) intensities, with a cos 4 dependence on the incident polarization. The TPL excitation spectrum can be superimposed onto the longitudinal plasmon band, indicating a plasmon-enhanced two-photon absorption cross section. The TPL signal from a single nanorod is 58 times that of the two-photon fluorescence signal from a single rhodamine molecule. The application of gold nanorods as TPL imaging agents is demonstrated by in vivo imaging of single nanorods flowing in mouse ear blood vessels.
Original language | English (US) |
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Pages (from-to) | 15752-15756 |
Number of pages | 5 |
Journal | Proceedings of the National Academy of Sciences of the United States of America |
Volume | 102 |
Issue number | 44 |
DOIs | |
State | Published - Nov 1 2005 |
Keywords
- In vivo imaging
- Multiphoton
- Nonlinear optics
- Plasmon resonance
ASJC Scopus subject areas
- Genetics
- General