TY - JOUR
T1 - In vitro activity of WIN 49375 compared with those of other antibiotics in isolates from cancer patients
AU - Garcia, I.
AU - Bodey, G. P.
AU - Fainstein, V.
AU - Ho, D. H.
AU - LeBlanc, B.
PY - 1984
Y1 - 1984
N2 - The activity of WIN 49375 [6-fluoro-1,4-dihydro-1-(methylamino)-7-(4-methyl-1-piperazinyl) -4-oxo-3-quinolinecarboxylic acid], a new synthetic quinolone, was tested in vitro against 587 clinical isolates. The MICs for 90% of isolates of Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae were 0.20, 1,56, and 0.39 μg/ml, respectively. The MICs for 90% of isolates of Pseudomonas aeruginosa and Serratia marcescens were both 3.12 μg/ml. WIN 49375 was minimally active against gram-positive cocci. Its in vitro activity suggests that it may be useful for the treatment of gram-negative bacillary infections.
AB - The activity of WIN 49375 [6-fluoro-1,4-dihydro-1-(methylamino)-7-(4-methyl-1-piperazinyl) -4-oxo-3-quinolinecarboxylic acid], a new synthetic quinolone, was tested in vitro against 587 clinical isolates. The MICs for 90% of isolates of Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae were 0.20, 1,56, and 0.39 μg/ml, respectively. The MICs for 90% of isolates of Pseudomonas aeruginosa and Serratia marcescens were both 3.12 μg/ml. WIN 49375 was minimally active against gram-positive cocci. Its in vitro activity suggests that it may be useful for the treatment of gram-negative bacillary infections.
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U2 - 10.1128/AAC.26.3.421
DO - 10.1128/AAC.26.3.421
M3 - Article
C2 - 6508271
AN - SCOPUS:0021135662
SN - 0066-4804
VL - 26
SP - 421
EP - 423
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 3
ER -