In vitro activity of telavancin compared with vancomycin and linezolid against gram-positive organisms isolated from cancer patients

Kenneth Vi Rolston, Weiqun Wang, Lior Nesher, Elizabeth Coyle, Samuel Shelburne, Randall A. Prince

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Telavancin is a dual action, bactericidal lipoglycopeptide. Its in vitro activity was compared with vancomycin and linezolid against 392 Gram-positive isolates from cancer patients. MIC 90 values (μg ml-1) for telavancin, vancomycin and linezolid were determined for methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resistant S. aureus (MRSA), methicillin-susceptible (MS), methicillin-resistant (MR), coagulase-negative staphylococci (CoNS), viridans group streptococci (VGS), Streptococcus pneumoniae, Bacillus species, Corynebacterium species and Micrococcus species. Telavancin had potent activity against β-hemolytic streptococci and Staphylococcus lugdunensis. Whereas 100% of MRSA and 98% of MSSA had vancomycin MICs ≥1.0 μg ml-1 (minimum inhibitory concentrations (MICs) at which poor clinical responses have been reported), the highest telavancin MIC was 0.38 μg ml-1. For CoNS, 95% of MS and 100% of MR isolates had vancomycin MICs ≥1.0 μg ml-1, whereas the highest telavancin MIC was 0.38 μg ml-1. Furthermore, 48% of VGS had vancomycin MICs ≥1.0 μg ml-1, whereas the highest telavancin MIC was 0.064 μg ml-1. A similar pattern was noticed for S. lugdunensis, Bacillus species, Corynebacterium species and β-hemolytic streptococci. These data suggest that telavancin and linezolid have potent activity against most Gram-positive organisms that cause infections in cancer patients. Consequently, they may be considered as alternatives to vancomycin, especially in institutions wherein a substantial proportion of infections are caused by organisms with vancomycin MICs ≥1.0 μg ml-1.

Original languageEnglish (US)
Pages (from-to)505-509
Number of pages5
JournalJournal of Antibiotics
Volume67
Issue number7
DOIs
StatePublished - Jan 1 2014

Keywords

  • cancer patient
  • Gram-positive
  • linezolid
  • telavancin
  • vancomycin

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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