In vitro activity of sulbactam-durlobactam against colistin-resistant and/or cefiderocol-non-susceptible, carbapenem-resistant Acinetobacter baumannii collected in U.S. hospitals

Alina Iovleva; Christi L. McElheny; Erin L. Fowler; Eric Cober; Erica S. Herc; Cesar A. Arias; Carol Hill; Keri Baum; Vance G. Fowler; Henry F. Chambers; Kerryl E. Greenwood-Quaintance; Robin Patel; David van Duin; Robert A. Bonomo; Yohei Doi

doi:10.1128/aac.01258-23

In vitro activity of sulbactam-durlobactam against colistin-resistant and/or cefiderocol-non-susceptible, carbapenem-resistant Acinetobacter baumannii collected in U.S. hospitals

Alina Iovleva, Christi L. McElheny, Erin L. Fowler, Eric Cober, Erica S. Herc, Cesar A. Arias, Carol Hill, Keri Baum, Vance G. Fowler, Henry F. Chambers, Kerryl E. Greenwood-Quaintance, Robin Patel, David van Duin, Robert A. Bonomo, Yohei Doi

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

The activity of a novel β-lactamase inhibitor combination, sulbactam-durlobactam (SUL-DUR), was tested against 87 colistin-resistant and/or cefiderocol-non-susceptible carbapenem-resistant Acinetobacter baumannii clinical isolates collected from U.S. hospitals between 2017 and 2019. Among them, 89% and 97% were susceptible to SUL-DUR and imipenem plus SUL-DUR, with MIC₅₀/MIC₉₀ values of 2 µg/mL/8 µg/mL and 1 µg/mL/4 µg/mL, respectively. The presence of amino acid substitutions in penicillin-binding protein 3, including previously reported A515V or T526S, was associated with SUL-DUR non-susceptibility.

Original language	English (US)
Pages (from-to)	e0125823
Journal	Antimicrobial Agents and Chemotherapy
Volume	68
Issue number	3
DOIs	https://doi.org/10.1128/aac.01258-23
State	Published - Mar 2024

Keywords

antimicrobial resistance
diazabicyclooctane
surveillance
Humans
Cefiderocol
Colistin/pharmacology
Anti-Bacterial Agents/pharmacology
Microbial Sensitivity Tests
Acinetobacter baumannii
Hospitals
Imipenem/pharmacology
Acinetobacter Infections/drug therapy
Sulbactam/pharmacology
Azabicyclo Compounds
Drug Combinations

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

Divisions

Infectious Disease

Access to Document

10.1128/aac.01258-23

Cite this

Iovleva, A., McElheny, C. L., Fowler, E. L., Cober, E., Herc, E. S., Arias, C. A., Hill, C., Baum, K., Fowler, V. G., Chambers, H. F., Greenwood-Quaintance, K. E., Patel, R., van Duin, D., Bonomo, R. A., & Doi, Y. (2024). In vitro activity of sulbactam-durlobactam against colistin-resistant and/or cefiderocol-non-susceptible, carbapenem-resistant Acinetobacter baumannii collected in U.S. hospitals. Antimicrobial Agents and Chemotherapy, 68(3), e0125823. https://doi.org/10.1128/aac.01258-23

In vitro activity of sulbactam-durlobactam against colistin-resistant and/or cefiderocol-non-susceptible, carbapenem-resistant Acinetobacter baumannii collected in U.S. hospitals. / Iovleva, Alina; McElheny, Christi L.; Fowler, Erin L. et al.
In: Antimicrobial Agents and Chemotherapy, Vol. 68, No. 3, 03.2024, p. e0125823.

Research output: Contribution to journal › Article › peer-review

Iovleva, A, McElheny, CL, Fowler, EL, Cober, E, Herc, ES, Arias, CA, Hill, C, Baum, K, Fowler, VG, Chambers, HF, Greenwood-Quaintance, KE, Patel, R, van Duin, D, Bonomo, RA & Doi, Y 2024, 'In vitro activity of sulbactam-durlobactam against colistin-resistant and/or cefiderocol-non-susceptible, carbapenem-resistant Acinetobacter baumannii collected in U.S. hospitals', Antimicrobial Agents and Chemotherapy, vol. 68, no. 3, pp. e0125823. https://doi.org/10.1128/aac.01258-23

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title = "In vitro activity of sulbactam-durlobactam against colistin-resistant and/or cefiderocol-non-susceptible, carbapenem-resistant Acinetobacter baumannii collected in U.S. hospitals",

abstract = "The activity of a novel β-lactamase inhibitor combination, sulbactam-durlobactam (SUL-DUR), was tested against 87 colistin-resistant and/or cefiderocol-non-susceptible carbapenem-resistant Acinetobacter baumannii clinical isolates collected from U.S. hospitals between 2017 and 2019. Among them, 89\% and 97\% were susceptible to SUL-DUR and imipenem plus SUL-DUR, with MIC50/MIC90 values of 2 µg/mL/8 µg/mL and 1 µg/mL/4 µg/mL, respectively. The presence of amino acid substitutions in penicillin-binding protein 3, including previously reported A515V or T526S, was associated with SUL-DUR non-susceptibility.",

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AU - Fowler, Erin L.

AU - Cober, Eric

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AU - Arias, Cesar A.

AU - Hill, Carol

AU - Baum, Keri

AU - Fowler, Vance G.

AU - Chambers, Henry F.

AU - Greenwood-Quaintance, Kerryl E.

AU - Patel, Robin

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AU - Bonomo, Robert A.

AU - Doi, Yohei

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KW - Hospitals

KW - Imipenem/pharmacology

KW - Acinetobacter Infections/drug therapy

KW - Sulbactam/pharmacology

KW - Azabicyclo Compounds

KW - Drug Combinations

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In vitro activity of sulbactam-durlobactam against colistin-resistant and/or cefiderocol-non-susceptible, carbapenem-resistant Acinetobacter baumannii collected in U.S. hospitals

Abstract

Keywords

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