In vitro activity of sulbactam-durlobactam against colistin-resistant and/or cefiderocol-non-susceptible, carbapenem-resistant Acinetobacter baumannii collected in U.S. hospitals

Alina Iovleva; Christi L. McElheny; Erin L. Fowler; Eric Cober; Erica S. Herc; Cesar A. Arias; Carol Hill; Keri Baum; Vance G. Fowler; Henry F. Chambers; Kerryl E. Greenwood-Quaintance; Robin Patel; David van Duin; Robert A. Bonomo; Yohei Doi

doi:10.1128/aac.01258-23

In vitro activity of sulbactam-durlobactam against colistin-resistant and/or cefiderocol-non-susceptible, carbapenem-resistant Acinetobacter baumannii collected in U.S. hospitals

Alina Iovleva, Christi L. McElheny, Erin L. Fowler, Eric Cober, Erica S. Herc, Cesar A. Arias, Carol Hill, Keri Baum, Vance G. Fowler, Henry F. Chambers, Kerryl E. Greenwood-Quaintance, Robin Patel, David van Duin, Robert A. Bonomo, Yohei Doi

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The activity of a novel β-lactamase inhibitor combination, sulbactam-durlobactam (SUL-DUR), was tested against 87 colistin-resistant and/or cefiderocol-non-susceptible carbapenem-resistant Acinetobacter baumannii clinical isolates collected from U.S. hospitals between 2017 and 2019. Among them, 89% and 97% were susceptible to SUL-DUR and imipenem plus SUL-DUR, with MIC₅₀/MIC₉₀ values of 2 µg/mL/8 µg/mL and 1 µg/mL/4 µg/mL, respectively. The presence of amino acid substitutions in penicillin-binding protein 3, including previously reported A515V or T526S, was associated with SUL-DUR non-susceptibility.

Original language	English (US)
Journal	Antimicrobial Agents and Chemotherapy
Volume	68
Issue number	3
DOIs	https://doi.org/10.1128/aac.01258-23
State	Published - Mar 2024

Keywords

antimicrobial resistance
diazabicyclooctane
surveillance

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/aac.01258-23

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Iovleva, A., McElheny, C. L., Fowler, E. L., Cober, E., Herc, E. S., Arias, C. A., Hill, C., Baum, K., Fowler, V. G., Chambers, H. F., Greenwood-Quaintance, K. E., Patel, R., van Duin, D., Bonomo, R. A., & Doi, Y. (2024). In vitro activity of sulbactam-durlobactam against colistin-resistant and/or cefiderocol-non-susceptible, carbapenem-resistant Acinetobacter baumannii collected in U.S. hospitals. Antimicrobial Agents and Chemotherapy, 68(3). https://doi.org/10.1128/aac.01258-23

In vitro activity of sulbactam-durlobactam against colistin-resistant and/or cefiderocol-non-susceptible, carbapenem-resistant Acinetobacter baumannii collected in U.S. hospitals. / Iovleva, Alina; McElheny, Christi L.; Fowler, Erin L. et al.
In: Antimicrobial Agents and Chemotherapy, Vol. 68, No. 3, 03.2024.

Research output: Contribution to journal › Article › peer-review

Iovleva, A, McElheny, CL, Fowler, EL, Cober, E, Herc, ES, Arias, CA, Hill, C, Baum, K, Fowler, VG, Chambers, HF, Greenwood-Quaintance, KE, Patel, R, van Duin, D, Bonomo, RA & Doi, Y 2024, 'In vitro activity of sulbactam-durlobactam against colistin-resistant and/or cefiderocol-non-susceptible, carbapenem-resistant Acinetobacter baumannii collected in U.S. hospitals', Antimicrobial Agents and Chemotherapy, vol. 68, no. 3. https://doi.org/10.1128/aac.01258-23

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title = "In vitro activity of sulbactam-durlobactam against colistin-resistant and/or cefiderocol-non-susceptible, carbapenem-resistant Acinetobacter baumannii collected in U.S. hospitals",

abstract = "The activity of a novel β-lactamase inhibitor combination, sulbactam-durlobactam (SUL-DUR), was tested against 87 colistin-resistant and/or cefiderocol-non-susceptible carbapenem-resistant Acinetobacter baumannii clinical isolates collected from U.S. hospitals between 2017 and 2019. Among them, 89% and 97% were susceptible to SUL-DUR and imipenem plus SUL-DUR, with MIC50/MIC90 values of 2 µg/mL/8 µg/mL and 1 µg/mL/4 µg/mL, respectively. The presence of amino acid substitutions in penicillin-binding protein 3, including previously reported A515V or T526S, was associated with SUL-DUR non-susceptibility.",

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In vitro activity of sulbactam-durlobactam against colistin-resistant and/or cefiderocol-non-susceptible, carbapenem-resistant Acinetobacter baumannii collected in U.S. hospitals

Abstract

Keywords

ASJC Scopus subject areas

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