In vitro activity of new cephalosporins against multi-resistant gramnegative bacteria

Victor Fainstein, Barbara Le Blanc, G. P. Bodey

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The in vitro sensitivities of 47 multi-resistant gram-negative bacilli against six third generation cephalosporins were investigated. Overall, moxalactam was the most active compound and cefoperazone the least active. Ceftizoxime and ceftazidime were very active against Enterobacteriaceae. Ceftriaxone and ceftizoxime were active against Escherichia coli and Klebsiella spp., but were inactive against Pseudomonas spp.;Achromobacter sp. was resistant to all drugs, while Citrobacter freundii was sensitive to every antibiotic tested. These drugs may be clinically useful in infections with multi-resistant gram-negative bacteria.

Original languageEnglish (US)
JournalInfection
Volume11
Issue number1 Supplement
DOIs
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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