In vitro activity of new cephalosporins against multi-resistant gramnegative bacteria

Victor Fainstein; Barbara Le Blanc; G. P. Bodey

doi:10.1007/BF01641100

In vitro activity of new cephalosporins against multi-resistant gramnegative bacteria

Victor Fainstein, Barbara Le Blanc, G. P. Bodey

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The in vitro sensitivities of 47 multi-resistant gram-negative bacilli against six third generation cephalosporins were investigated. Overall, moxalactam was the most active compound and cefoperazone the least active. Ceftizoxime and ceftazidime were very active against Enterobacteriaceae. Ceftriaxone and ceftizoxime were active against Escherichia coli and Klebsiella spp., but were inactive against Pseudomonas spp.;Achromobacter sp. was resistant to all drugs, while Citrobacter freundii was sensitive to every antibiotic tested. These drugs may be clinically useful in infections with multi-resistant gram-negative bacteria.

Original language	English (US)
Journal	Infection
Volume	11
Issue number	1 Supplement
DOIs	https://doi.org/10.1007/BF01641100
State	Published - Jan 1 1983

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1007/BF01641100

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title = "In vitro activity of new cephalosporins against multi-resistant gramnegative bacteria",

abstract = "The in vitro sensitivities of 47 multi-resistant gram-negative bacilli against six third generation cephalosporins were investigated. Overall, moxalactam was the most active compound and cefoperazone the least active. Ceftizoxime and ceftazidime were very active against Enterobacteriaceae. Ceftriaxone and ceftizoxime were active against Escherichia coli and Klebsiella spp., but were inactive against Pseudomonas spp.;Achromobacter sp. was resistant to all drugs, while Citrobacter freundii was sensitive to every antibiotic tested. These drugs may be clinically useful in infections with multi-resistant gram-negative bacteria.",

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AU - Le Blanc, Barbara

AU - Bodey, G. P.

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N2 - The in vitro sensitivities of 47 multi-resistant gram-negative bacilli against six third generation cephalosporins were investigated. Overall, moxalactam was the most active compound and cefoperazone the least active. Ceftizoxime and ceftazidime were very active against Enterobacteriaceae. Ceftriaxone and ceftizoxime were active against Escherichia coli and Klebsiella spp., but were inactive against Pseudomonas spp.;Achromobacter sp. was resistant to all drugs, while Citrobacter freundii was sensitive to every antibiotic tested. These drugs may be clinically useful in infections with multi-resistant gram-negative bacteria.

AB - The in vitro sensitivities of 47 multi-resistant gram-negative bacilli against six third generation cephalosporins were investigated. Overall, moxalactam was the most active compound and cefoperazone the least active. Ceftizoxime and ceftazidime were very active against Enterobacteriaceae. Ceftriaxone and ceftizoxime were active against Escherichia coli and Klebsiella spp., but were inactive against Pseudomonas spp.;Achromobacter sp. was resistant to all drugs, while Citrobacter freundii was sensitive to every antibiotic tested. These drugs may be clinically useful in infections with multi-resistant gram-negative bacteria.

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ER -

In vitro activity of new cephalosporins against multi-resistant gramnegative bacteria

Abstract

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