In vitro activity of azithromycin against bacterial enteric pathogens

M. E. Gordillo, K. V. Singh, B. E. Murray

Research output: Contribution to journalArticlepeer-review

Abstract

The in vitro activity of azithromycin against enteric bacterial pathogens was determined by agar dilution. Azithromycin was highly active against Campylobacter spp. (MIC for 90% of strains tested [MIC90] = 0.125 μg/ml) and against enterotoxigenic, enterohemorrhagic, enteroinvasive, and enteropathogenic Escherichia coli (MIC90 = 2 μg/ml), Shigella spp. (MIC90 = 1 μg/ml), and Salmonella spp. (MIC90 = 4 μg/ml), including Salmonella typhi (MIC90 = 1 μg/ml). On the basis of the in vitro activity of the drug against these organisms, clinical studies of azithromycin in enteric diseases should be considered; the high intracellular concentrations achieved by azithromycin may be particularly relevant for organisms like S. typhi, Campylobacter spp., and Shigella spp. which typically invade cells as part of their infectious process.

Original languageEnglish (US)
Pages (from-to)1203-1205
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume37
Issue number5
DOIs
StatePublished - 1993

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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