In vitro activities of oxazolidinones U-100592 and U-100766 against penicillin-resistant and cephalosporin-resistant strains of Streptococcus pneumoniae

Edward O. Mason, Linda B. Lamberth, Sheldon L. Kaplan

Research output: Contribution to journalComment/debate

58 Scopus citations

Abstract

Two oxazolidinones and ceftriaxone, imipenem, rifampin, and vancomycin were tested against 162 penicillin-intermediate and 68 penicillin-resistant strains of pneumococci. U-100592 is two- to fourfold more active than U- 100766 against penicillin-resistant pneumococci. The MICs of U-100592 at which 90% of the isolates were inhibited were 0.25 and 0.5 μg/ml for penicillin-intermediate and -resistant strains, respectively, and 0.5 μg/ml for ceftriaxone-susceptible, -intermediate, and -resistant strains. U-100592 MICs for 7 of 230 strains (2 from blond, 3 from middle-ear fluid, and 2 from the upper respiratory tract) were 1 μg/ml.

Original languageEnglish (US)
Pages (from-to)1039-1040
Number of pages2
JournalAntimicrobial Agents and Chemotherapy
Volume40
Issue number4
DOIs
StatePublished - Apr 1996

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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