TY - JOUR
T1 - In vitro activities of oxazolidinones U-100592 and U-100766 against penicillin-resistant and cephalosporin-resistant strains of Streptococcus pneumoniae
AU - Mason, Edward O.
AU - Lamberth, Linda B.
AU - Kaplan, Sheldon L.
PY - 1996/4
Y1 - 1996/4
N2 - Two oxazolidinones and ceftriaxone, imipenem, rifampin, and vancomycin were tested against 162 penicillin-intermediate and 68 penicillin-resistant strains of pneumococci. U-100592 is two- to fourfold more active than U- 100766 against penicillin-resistant pneumococci. The MICs of U-100592 at which 90% of the isolates were inhibited were 0.25 and 0.5 μg/ml for penicillin-intermediate and -resistant strains, respectively, and 0.5 μg/ml for ceftriaxone-susceptible, -intermediate, and -resistant strains. U-100592 MICs for 7 of 230 strains (2 from blond, 3 from middle-ear fluid, and 2 from the upper respiratory tract) were 1 μg/ml.
AB - Two oxazolidinones and ceftriaxone, imipenem, rifampin, and vancomycin were tested against 162 penicillin-intermediate and 68 penicillin-resistant strains of pneumococci. U-100592 is two- to fourfold more active than U- 100766 against penicillin-resistant pneumococci. The MICs of U-100592 at which 90% of the isolates were inhibited were 0.25 and 0.5 μg/ml for penicillin-intermediate and -resistant strains, respectively, and 0.5 μg/ml for ceftriaxone-susceptible, -intermediate, and -resistant strains. U-100592 MICs for 7 of 230 strains (2 from blond, 3 from middle-ear fluid, and 2 from the upper respiratory tract) were 1 μg/ml.
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U2 - 10.1128/aac.40.4.1039
DO - 10.1128/aac.40.4.1039
M3 - Comment/debate
C2 - 8849225
AN - SCOPUS:0029922958
SN - 0066-4804
VL - 40
SP - 1039
EP - 1040
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 4
ER -