In vitro activities of a new ketolide, ABT-773, against multidrug-resistant gram-positive cocci

K. V. Singh; K. Malathum; B. E. Murray

doi:10.1128/AAC.45.12.3640-3643.2001

In vitro activities of a new ketolide, ABT-773, against multidrug-resistant gram-positive cocci

K. V. Singh, K. Malathum, B. E. Murray

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The in vitro activities of ABT-773 were evaluated against 324 strains of gram-positive bacteria, including multidrug-resistant Staphylococcus spp. and Enterococcus spp. ABT-773 had lower MIC ranges, MICs at which 50% of isolates are inhibited (MIC₅₀s), and MIC₉₀s than erythromycin or clindamycin for almost all isolates tested. The MICs of ABT-773 were also lower than those of quinupristin-dalfopristin (Q-D) for methicillin-susceptible Staphylococcus aureus, Rhodococcus spp., and Streptococcus spp., while the MICs of Q-D were lower than those of ABT-773 for methicillin-resistant S. aureus and Enterococcus faecium, including vancomycin-resistant isolates.

Original language	English (US)
Pages (from-to)	3640-3643
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	45
Issue number	12
DOIs	https://doi.org/10.1128/AAC.45.12.3640-3643.2001
State	Published - 2001

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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Infectious Disease

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10.1128/AAC.45.12.3640-3643.2001

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title = "In vitro activities of a new ketolide, ABT-773, against multidrug-resistant gram-positive cocci",

abstract = "The in vitro activities of ABT-773 were evaluated against 324 strains of gram-positive bacteria, including multidrug-resistant Staphylococcus spp. and Enterococcus spp. ABT-773 had lower MIC ranges, MICs at which 50\% of isolates are inhibited (MIC50s), and MIC90s than erythromycin or clindamycin for almost all isolates tested. The MICs of ABT-773 were also lower than those of quinupristin-dalfopristin (Q-D) for methicillin-susceptible Staphylococcus aureus, Rhodococcus spp., and Streptococcus spp., while the MICs of Q-D were lower than those of ABT-773 for methicillin-resistant S. aureus and Enterococcus faecium, including vancomycin-resistant isolates.",

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AU - Murray, B. E.

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AB - The in vitro activities of ABT-773 were evaluated against 324 strains of gram-positive bacteria, including multidrug-resistant Staphylococcus spp. and Enterococcus spp. ABT-773 had lower MIC ranges, MICs at which 50% of isolates are inhibited (MIC50s), and MIC90s than erythromycin or clindamycin for almost all isolates tested. The MICs of ABT-773 were also lower than those of quinupristin-dalfopristin (Q-D) for methicillin-susceptible Staphylococcus aureus, Rhodococcus spp., and Streptococcus spp., while the MICs of Q-D were lower than those of ABT-773 for methicillin-resistant S. aureus and Enterococcus faecium, including vancomycin-resistant isolates.

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In vitro activities of a new ketolide, ABT-773, against multidrug-resistant gram-positive cocci

Abstract

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