In vitro activities of a new ketolide, ABT-773, against multidrug-resistant gram-positive cocci

K. V. Singh, K. Malathum, B. E. Murray

Research output: Contribution to journalArticlepeer-review

Abstract

The in vitro activities of ABT-773 were evaluated against 324 strains of gram-positive bacteria, including multidrug-resistant Staphylococcus spp. and Enterococcus spp. ABT-773 had lower MIC ranges, MICs at which 50% of isolates are inhibited (MIC50s), and MIC90s than erythromycin or clindamycin for almost all isolates tested. The MICs of ABT-773 were also lower than those of quinupristin-dalfopristin (Q-D) for methicillin-susceptible Staphylococcus aureus, Rhodococcus spp., and Streptococcus spp., while the MICs of Q-D were lower than those of ABT-773 for methicillin-resistant S. aureus and Enterococcus faecium, including vancomycin-resistant isolates.

Original languageEnglish (US)
Pages (from-to)3640-3643
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume45
Issue number12
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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