In utero exposure to fluoxetine HCl increases hematoma frequency at birth

Matthew S. Stanford, Jim H. Patton

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

The present study was undertaken to determine if fluoxetine HCl (Prozac, Dista Products Ltd., Liverpool, UK) might cause adverse vascular effects, such as hematomas, in rats exposed in utero. Gravid Sprague-Dawley rats were administered 5.62 mg/kg fluoxetine HCl by oral gavage beginning on day 7 of gestation and ending the day of birth. A control group received distilled water by oral gavage during gestation. At birth, offspring of both groups were assessed for visible adverse vascular effects. Fluoxetine HCl-exposed offspring showed a statistically higher frequency of skin hematomas when compared to water controls. This result is consistent with known adverse effects of fluoxetine and lends support to a recently published report that attempted to link fluoxetine HCl use to bleeding episodes in eight patients being treated for obsessive-compulsive disorder. The results of this study suggest caution in the prolonged use of this medication during pregnancy and in patients with predisposing conditions that may increase the chances of bleeding.

Original languageEnglish (US)
Pages (from-to)959-962
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume45
Issue number4
DOIs
StatePublished - Jan 1 1993

Keywords

  • Fluoxetine
  • Prenatal drug effects
  • Serotonin
  • Vascular effects

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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