In Situ Self-Assembled Nanofibers Precisely Target Cancer-Associated Fibroblasts for Improved Tumor Imaging

Xiao Xiao Zhao, Li Li Li, Ying Zhao, Hong Wei An, Qian Cai, Jia Yan Lang, Xue Xiang Han, Bo Peng, Yue Fei, Hao Liu, Hao Qin, Guangjun Nie, Hao Wang

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Tumor complexity makes the development of highly sensitive tumor imaging probes an arduous task. Here, we construct a peptide-based near-infrared probe that is responsive to fibroblast activation protein-α (FAP-α), and specifically forms nanofibers on the surface of cancer-associated fibroblasts (CAFs) in situ. The assembly/aggregation-induced retention (AIR) effect results in enhanced accumulation and retention of the probe around the tumor, resulting in a 5.5-fold signal enhancement in the tumor 48 h after administration compared to that of a control molecule that does not aggregate. The probe provides a prolonged detectable window of 48 h for tumor diagnosis. The selective assembly of the probe results in a signal intensity over four- and fivefold higher in tumor than in the liver and kidney, respectively. With enhanced tumor imaging capability, this probe can visualize small tumors around 2 mm in diameter.

Original languageEnglish (US)
Pages (from-to)15287-15294
Number of pages8
JournalAngewandte Chemie - International Edition
Volume58
Issue number43
DOIs
StatePublished - Oct 21 2019

Keywords

  • cancer-associated fibroblasts
  • cyanine
  • peptides
  • self-assembly
  • tumor imaging

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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