In Situ Reductive Synthesis of Structural Supported Gold Nanorods in Porous Silicon Particles for Multifunctional Nanovectors

Guixian Zhu, Jen Tsai Liu, Yuzhen Wang, Dechen Zhang, Yi Guo, Ennio Tasciotti, Zhongbo Hu, Xuewu Liu

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Porous silicon nanodisks (PSD) were fabricated by the combination of photolithography and electrochemical etching of silicon. By using PSD as a reducing agent, gold nanorods (AuNR) were in situ synthesized in the nanopores of PSD, forming PSD-supported-AuNR (PSD/AuNR) hybrid particles. The formation mechanism of AuNR in porous silicon (pSi) was revealed by exploring the role of pSi reducibility and each chemical in the reaction. With the PSD support, AuNR exhibited a stable morphology without toxic surface ligands (CTAB). The PSD/AuNR hybrid particles showed enhanced plasmonic property compared to free AuNR. Because high-density "hot spots" can be generated by controlling the distribution of AuNR supported in PSD, surface-enhanced raman scattering (SERS) using PSD/AuNR as particle substrates was demonstrated. A multifunctional vector, PSD/AuNR/DOX, composed of doxorubicin (DOX)-loaded PSD/AuNR capped with agarose (agar), was developed for highly efficient, combinatorial cancer treatment. Their therapeutic efficacy was examined using two pancreatic cancer cell lines, PANC-1 and MIA PaCa-2. PSD/AuNR/DOX (20 μg Au and 1.25 μg DOX/mL) effectively destroyed these cells under near-IR laser irradiation (810 nm, 15 J·cm-2 power, 90 s). Overall, we envision that PSD/AuNR may be a promising injectable, multifunctional nanovector for biomedical application.

Original languageEnglish (US)
Pages (from-to)11881-11891
Number of pages11
JournalACS Applied Materials and Interfaces
Volume8
Issue number18
DOIs
StatePublished - May 11 2016

Keywords

  • SERS
  • on-site synthesis
  • photothermal therapy
  • plasmonic gold nanorod
  • porous silicon particles

ASJC Scopus subject areas

  • Materials Science(all)

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