In silico Kinetic Model of iNOS expression in macrophages

Taha Salim; Elebeoba E. May

doi:10.1109/EMBC.2014.6943801

In silico Kinetic Model of iNOS expression in macrophages

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Macrophages are a key component in the host innate response and are major contributors to the proinflammatory response against pathogens. One of the key players in the proinflammatory response is induced nitric oxide synthase (iNOS), an enzyme that provides the nitric oxide needed by phagocytic cells to create reactive nitrogen species, which are highly damaging to intracellular pathogens. To model the macrophage intracellular mechanism of iNOS gene expression, we use a systems biology approach to capture the dynamics of the iNOS gene expression system stimulated by bacterial lipopolysaccharide (LPS) and IFN-y. Our simulation results agree with in vitro assays of iNOS gene expression and provide a platform for further investigating the potential impact of LPS and IFN-y variations on macrophage effector function.

Original language	English (US)
Title of host publication	2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Subtitle of host publication	EMBC 2014
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	1159-1161
Number of pages	3
Volume	2014
ISBN (Print)	9781424479290
DOIs	https://doi.org/10.1109/EMBC.2014.6943801 https://doi.org/10.1109/EMBC.2014.6943801
State	Published - Nov 2 2014
Event	2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 - Chicago, United States Duration: Aug 26 2014 → Aug 30 2014

Other

Other	2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
Country/Territory	United States
City	Chicago
Period	8/26/14 → 8/30/14

ASJC Scopus subject areas

Health Informatics
Computer Science Applications
Biomedical Engineering

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Salim, T., & May, E. E. (2014). In silico Kinetic Model of iNOS expression in macrophages. In 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society : EMBC 2014 (Vol. 2014, pp. 1159-1161). [6943801] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2014.6943801, https://doi.org/10.1109/EMBC.2014.6943801

In silico Kinetic Model of iNOS expression in macrophages. / Salim, Taha; May, Elebeoba E.

2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society : EMBC 2014. Vol. 2014 Institute of Electrical and Electronics Engineers Inc., 2014. p. 1159-1161 6943801.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Salim, T & May, EE 2014, In silico Kinetic Model of iNOS expression in macrophages. in 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society : EMBC 2014. vol. 2014, 6943801, Institute of Electrical and Electronics Engineers Inc., pp. 1159-1161, 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014, Chicago, United States, 8/26/14. https://doi.org/10.1109/EMBC.2014.6943801, https://doi.org/10.1109/EMBC.2014.6943801

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In silico Kinetic Model of iNOS expression in macrophages

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