In silico evaluation of pharmacokinetic parameters, delivery, distribution and anticoagulative effects of new 4,7-dihydroxycoumarin derivative

Keyphrases

• Warfarin 100%
• Pharmacokinetic Parameters 100%
• In Silico Evaluation 100%
• 4,7-dihydroxycoumarin 100%
• Active Sites 42%
• Binding Affinity 42%
• Human Serum Albumin 28%
• Inhibitory Activity 28%
• Liver 14%
• Diffusive Transport 14%
• Blood Vessels 14%
• High Affinity 14%
• Vitamin K Antagonists 14%
• Anticoagulants 14%
• Pulmonary Embolism 14%
• Amino 14%
• Blood Tissue 14%
• Ethylidene 14%
• Molecular Dynamics Simulation 14%
• Ischemic Heart Disease 14%
• Acetate 14%
• Anticoagulant Activity 14%
• Plasma Proteins 14%
• Finite Element 14%
• Comparative Analysis 14%
• Amino Acid Residues 14%
• Molecular Docking 14%
• Docking Dynamics 14%
• Coumarin Derivatives 14%
• Pharmacological Profile 14%
• Venous Thrombosis 14%
• Oral Anticoagulants 14%
• Transport Model 14%
• Methoxyphenyl 14%
• Convection-diffusion 14%
• Inhibitory Potential 14%
• Smeared Model 14%
• Affinity Analysis 14%
• Spectrofluorimetric Method 14%
• 2,4-Dioxochroman 14%
• Static Process 14%

Biochemistry, Genetics and Molecular Biology

• Active Site 100%
• Binding Affinity 100%
• Pharmacokinetic 100%
• Human Serum Albumin 66%
• Enzyme 33%
• Facilitated Diffusion 33%
• Amino Acid 33%
• Vitamin K 33%
• Anticoagulation 33%
• Serum Total Protein 33%
• Phlebothrombosis 33%
• Docking (Molecular) 33%
• Coumarin 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Warfarin 100%
• Pharmacokinetic Parameter 100%
• Anticoagulant Agent 28%
• Human Serum Albumin 28%
• Receptor 14%
• Amino Acid 14%
• Ischemic Heart Disease 14%
• Plasma Protein 14%
• Lung Embolism 14%
• Anticoagulant Activity 14%
• Coumarin Derivative 14%
• Vein Thrombosis 14%
• Antivitamin K 14%