In-hospital cerebrovascular complications following orthotopic liver transplantation: A retrospective study

Li Ling, Xiaoshun He, Jinsheng Zeng, Zhijian Liang

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Background: Cerebrovascular complications are severe events following orthotopic liver transplantation (OLT). This study aimed to observe the clinical and neuroimaging features and possible risk factors of in-hospital cerebrovascular complications in the patients who underwent OLT. Patients and methods: We retrospectively reviewed 337 consecutive patients who underwent 358 OLTs. Cerebrovascular complications were determined by clinical and neuroimaging manifestations, and the possible risk factors were analyzed in the patients with intracranial hemorrhage. Results: Ten of 337 (3.0%) patients developed in-hospital cerebrovascular complications (8 cases experienced intracranial hemorrhage and 2 cases had cerebral infarction), and 6 of them died. The clinical presentations were similar to common stroke, but with rapid deterioration at early stage. The hematomas on brain CT scan were massive, irregular, multifocal and diffuse, and most of them were located at brain lobes and might enlarge or rebleed. Infarcts presented lacunar and multifocal lesions in basal gangliar but with possible hemorrhagic transformation. The patients with intracranial hemorrhage had older age and a more frequency of systemic infection than non-intracranial hemorrhage patients. (P = 0.011 and 0.029, respectively). Conclusion: Posttransplant cerebrovascular complications have severe impact on outcome of the patients who received OLT. Older age and systemic infection may be the possible risk factors of in-hospital intracranial hemorrhage following OLT.

Original languageEnglish (US)
Article number52
JournalBMC neurology
Issue number1
StatePublished - Dec 2008


  • Cerebral Infarction
  • Decompressive Craniectomy
  • Intracranial Hemorrhage
  • Orthotopic Liver Transplantation
  • Systemic Infection

ASJC Scopus subject areas

  • Clinical Neurology


Dive into the research topics of 'In-hospital cerebrovascular complications following orthotopic liver transplantation: A retrospective study'. Together they form a unique fingerprint.

Cite this