In-hospital central nervous system complications after liver transplantation

Li Ling, Xiaoshun He, Jin Sheng Zeng, Zhi Jian Liang

Research output: Contribution to journalArticle

Abstract

Objective: To explore the incidence, clinical and neuroimaging features, possible risk factors and outcome of in-hospital central nervous system complications after orthotopic liver transplantation (OLT). Methods: 337 consecutive patients who underwent 358 OLTs at the first affiliated hospital, Sun Yet-Sen University during January 1996 through June 2005 were retrospectively analyzed, focusing on their clinical and neuroimaging features of the in-hospital central nervous system complications after OLT. The comparison of the possible risk factors and outcome was made between patients with or without central nervous system complications. Results: Fifty-eight patients developed in-hospital central nervous system complications after OLT. The incidence was 16.2% and the mortality rate was 41.4%. The most common central nervous system complication was encephalopathy (10.3%), next was seizures (4.5%). 10 patients (2.8%) had cerebralvascular complications (8 patients with cerebral hemorrhage and 2 with cerebral infarction). Significant differences of age, retransplantation and the mortality rate existed between the patients with and without central nervous system complications. Conclusions: There was a high incidence and mortality rate of in-hospital central nervous system complications after OLT, which had a impact on quality of life and outcome of patients underwent OLT. Age, retransplantation may be the possible risk factors of central nervous system complications after OLT.

Original languageEnglish (US)
Pages (from-to)264-267
Number of pages4
JournalChinese Journal of Neurology
Volume40
Issue number4
StatePublished - Apr 1 2007

Keywords

  • Central nervous system disease
  • Liver transplantation
  • Prognosis
  • Risk factors

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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