Improved, shorter-latency carcinogen-induced hepatocellular carcinoma model in pigs

Jason Ho, Matthew Ware, Justin Law, Aaditya Nagaraj, Shilpa Jain, Jesse Rios, Reynaldo Calderon, Barry Toombs, Andrew Anderson, Collin Bray, Steven Curley, Stuart James Corr

Research output: Contribution to journalArticlepeer-review

Abstract

Large animal models are important tools for hepatocellular carcinoma (HCC) research, especially in studies of hepatic vasculature, interventional techniques, and radiofrequency or microwave hyperthermia. Currently, diethylnitrosamine (DENA)-induced HCC in pigs is the only large animal model for in situ HCC with a tumor latency of 10-26 months. While phenobarbital (PB) is often used to accelerate DENA-induced HCC in rodents, it has not been previously studied in the porcine model. Therefore, we hypothesize that the addition of PB in the DENA-induced HCC porcine model will accelerate tumor latency compared to DENA alone. HCC and benign lesions were seen on serial MRI and confirmed on histopathology. Liver and tumors were further characterized by CT angiography, vascular corrosion casting, and permittivity measurements.

Original languageEnglish (US)
Pages (from-to)360-369
Number of pages10
JournalOncology (Switzerland)
Volume95
Issue number6
DOIs
StatePublished - Nov 1 2018

Keywords

  • Diethylnitrosamine
  • Hepatocellular carcinoma
  • Phenobarbital
  • Porcine

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint

Dive into the research topics of 'Improved, shorter-latency carcinogen-induced hepatocellular carcinoma model in pigs'. Together they form a unique fingerprint.

Cite this