Abstract
Previously, TX5179, a disruption mutant of the enterococcal polysaccharide antigen (epa) gene cluster of Enterococcusfaecalis strain OGlRF was shown to be attenuated in translocation, biofilm, mouse peritonitis and was more susceptible to polymorphonuclear leukocyte phagocytic killing. Here, wild-type E. faecalis OGlRF and TX5179 strains were tested in a mixed-infection (inoculum, -1:1) mouse urinary tract infection model. Wild-type OGlRF outnumbered TX5179 in the kidneys (P < .001) and bladder (P < .001). In conclusion, the epa locus of E. faecalis OGlRF contributes to murine urinary tract infection and is the first such enterococcal polysaccharide locus shown to be important in this site.
Original language | English (US) |
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Pages (from-to) | 417-420 |
Number of pages | 4 |
Journal | Journal of Infectious Diseases |
Volume | 200 |
Issue number | 3 |
DOIs | |
State | Published - Aug 1 2009 |
ASJC Scopus subject areas
- Immunology and Allergy
- Infectious Diseases