Importance of the epa locus of enterococcus faecalis OGlRF in a mouse model of ascending urinary tract infection

Kavindra V. Singh, Roshan J. Lewis, Barbara E. Murray

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Previously, TX5179, a disruption mutant of the enterococcal polysaccharide antigen (epa) gene cluster of Enterococcusfaecalis strain OGlRF was shown to be attenuated in translocation, biofilm, mouse peritonitis and was more susceptible to polymorphonuclear leukocyte phagocytic killing. Here, wild-type E. faecalis OGlRF and TX5179 strains were tested in a mixed-infection (inoculum, -1:1) mouse urinary tract infection model. Wild-type OGlRF outnumbered TX5179 in the kidneys (P < .001) and bladder (P < .001). In conclusion, the epa locus of E. faecalis OGlRF contributes to murine urinary tract infection and is the first such enterococcal polysaccharide locus shown to be important in this site.

Original languageEnglish (US)
Pages (from-to)417-420
Number of pages4
JournalJournal of Infectious Diseases
Volume200
Issue number3
DOIs
StatePublished - Aug 1 2009

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Fingerprint

Dive into the research topics of 'Importance of the epa locus of enterococcus faecalis OGlRF in a mouse model of ascending urinary tract infection'. Together they form a unique fingerprint.

Cite this