TY - JOUR
T1 - Importance of Myocardial Fibrosis in Functional Mitral Regurgitation
T2 - From Outcomes to Decision-Making
AU - Lopes, Bernardo B.C.
AU - Kwon, Deborah H.
AU - Shah, Dipan J.
AU - Lesser, John R.
AU - Bapat, Vinayak
AU - Enriquez-Sarano, Maurice
AU - Sorajja, Paul
AU - Cavalcante, João L.
N1 - Publisher Copyright:
© 2021 American College of Cardiology Foundation
PY - 2021/4
Y1 - 2021/4
N2 - Functional mitral regurgitation (FMR) is a common and complex valve disease, in which severity and risk stratification is still a conundrum. Although risk increases with FMR severity, it is modulated by subjacent left ventricular (LV) disease. The extent of LV remodeling and dysfunction is traditionally evaluated by echocardiography, but a growing body of evidence shows that myocardial fibrosis (MF) assessment by cardiac magnetic resonance (CMR) may complement risk stratification and inform treatment decisions. This review summarizes the current knowledge on the comprehensive evaluation that CMR can provide for patients with FMR, in particular for the assessment of MF and its potential impact in clinical decision-making.
AB - Functional mitral regurgitation (FMR) is a common and complex valve disease, in which severity and risk stratification is still a conundrum. Although risk increases with FMR severity, it is modulated by subjacent left ventricular (LV) disease. The extent of LV remodeling and dysfunction is traditionally evaluated by echocardiography, but a growing body of evidence shows that myocardial fibrosis (MF) assessment by cardiac magnetic resonance (CMR) may complement risk stratification and inform treatment decisions. This review summarizes the current knowledge on the comprehensive evaluation that CMR can provide for patients with FMR, in particular for the assessment of MF and its potential impact in clinical decision-making.
KW - cardiac magnetic resonance
KW - functional mitral regurgitation
KW - myocardial fibrosis
KW - secondary mitral regurgitation
KW - Mitral Valve Insufficiency/diagnostic imaging
KW - Predictive Value of Tests
KW - Ventricular Remodeling
KW - Humans
KW - Fibrosis
KW - Cardiomyopathies
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U2 - 10.1016/j.jcmg.2020.10.027
DO - 10.1016/j.jcmg.2020.10.027
M3 - Review article
C2 - 33582069
AN - SCOPUS:85101715801
SN - 1936-878X
VL - 14
SP - 867
EP - 878
JO - JACC: Cardiovascular Imaging
JF - JACC: Cardiovascular Imaging
IS - 4
ER -