Implications of tumor location on subtypes of medulloblastoma

Wan Yee Teo; Jianhe Shen; Jack Meng Fen Su; Alexander Yu; Jian Wang; Wing Yuk Chow; Xiaonan Li; Jeremy Jones; Robert Dauser; William Whitehead; Adekunle M. Adesina; Murali Chintagumpala; Tsz Kwong Man; Ching C. Lau

doi:10.1002/pbc.24511

Implications of tumor location on subtypes of medulloblastoma

Wan Yee Teo, Jianhe Shen, Jack Meng Fen Su, Alexander Yu, Jian Wang, Wing Yuk Chow, Xiaonan Li, Jeremy Jones, Robert Dauser, William Whitehead, Adekunle M. Adesina, Murali Chintagumpala, Tsz Kwong Man, Ching C. Lau

Houston Methodist

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

Background: Medulloblastoma (MB) comprises of four molecular subtypes, Sonic hedgehog (SHH), Wingless (WNT), Groups 3 and 4. WNT-subtype MBs were found to arise from midline of the brainstem occupying the fourth ventricle while SHH-subtype occupied the cerebellar hemisphere in a small subset of patients. Procedure: We tested this hypothesis in a large cohort of pediatric MBs comprising of all four molecular subtypes. Results: We validated in the first comprehensive analysis of tumor location of 60 human MBs representative of the four molecular subtypes, that hemispheric tumors are significantly associated with SHH-subtype MBs while midline tumors with WNT-subtype, Group 3 and 4 MBs (P<0.001). Nearly half of SHH-subtype MBs were midline. Conclusions: Tumor location should not be generalized to MB subtypes. SHH-subtype MBs are not exclusively hemispheric and hemispheric MBs are not always SHH-activated. It is imperative to identify subtypes in conjunction with tumor location when exploring currently available targeted therapy.

Original language	English (US)
Pages (from-to)	1408-1410
Number of pages	3
Journal	Pediatric Blood and Cancer
Volume	60
Issue number	9
DOIs	https://doi.org/10.1002/pbc.24511
State	Published - Sep 2013

Keywords

Medulloblastoma
Molecular subtypes
Pediatric
Tumor location

ASJC Scopus subject areas

Oncology
Pediatrics, Perinatology, and Child Health
Hematology

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10.1002/pbc.24511

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@article{e13ce1057c5c4259a443a7fdaab74708,

title = "Implications of tumor location on subtypes of medulloblastoma",

abstract = "Background: Medulloblastoma (MB) comprises of four molecular subtypes, Sonic hedgehog (SHH), Wingless (WNT), Groups 3 and 4. WNT-subtype MBs were found to arise from midline of the brainstem occupying the fourth ventricle while SHH-subtype occupied the cerebellar hemisphere in a small subset of patients. Procedure: We tested this hypothesis in a large cohort of pediatric MBs comprising of all four molecular subtypes. Results: We validated in the first comprehensive analysis of tumor location of 60 human MBs representative of the four molecular subtypes, that hemispheric tumors are significantly associated with SHH-subtype MBs while midline tumors with WNT-subtype, Group 3 and 4 MBs (P<0.001). Nearly half of SHH-subtype MBs were midline. Conclusions: Tumor location should not be generalized to MB subtypes. SHH-subtype MBs are not exclusively hemispheric and hemispheric MBs are not always SHH-activated. It is imperative to identify subtypes in conjunction with tumor location when exploring currently available targeted therapy.",

keywords = "Medulloblastoma, Molecular subtypes, Pediatric, Tumor location",

author = "Teo, {Wan Yee} and Jianhe Shen and Su, {Jack Meng Fen} and Alexander Yu and Jian Wang and Chow, {Wing Yuk} and Xiaonan Li and Jeremy Jones and Robert Dauser and William Whitehead and Adesina, {Adekunle M.} and Murali Chintagumpala and Man, {Tsz Kwong} and Lau, {Ching C.}",

year = "2013",

month = sep,

doi = "10.1002/pbc.24511",

language = "English (US)",

volume = "60",

pages = "1408--1410",

journal = "Pediatric Blood and Cancer",

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publisher = "Wiley",

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TY - JOUR

T1 - Implications of tumor location on subtypes of medulloblastoma

AU - Teo, Wan Yee

AU - Shen, Jianhe

AU - Su, Jack Meng Fen

AU - Yu, Alexander

AU - Wang, Jian

AU - Chow, Wing Yuk

AU - Li, Xiaonan

AU - Jones, Jeremy

AU - Dauser, Robert

AU - Whitehead, William

AU - Adesina, Adekunle M.

AU - Chintagumpala, Murali

AU - Man, Tsz Kwong

AU - Lau, Ching C.

PY - 2013/9

Y1 - 2013/9

N2 - Background: Medulloblastoma (MB) comprises of four molecular subtypes, Sonic hedgehog (SHH), Wingless (WNT), Groups 3 and 4. WNT-subtype MBs were found to arise from midline of the brainstem occupying the fourth ventricle while SHH-subtype occupied the cerebellar hemisphere in a small subset of patients. Procedure: We tested this hypothesis in a large cohort of pediatric MBs comprising of all four molecular subtypes. Results: We validated in the first comprehensive analysis of tumor location of 60 human MBs representative of the four molecular subtypes, that hemispheric tumors are significantly associated with SHH-subtype MBs while midline tumors with WNT-subtype, Group 3 and 4 MBs (P<0.001). Nearly half of SHH-subtype MBs were midline. Conclusions: Tumor location should not be generalized to MB subtypes. SHH-subtype MBs are not exclusively hemispheric and hemispheric MBs are not always SHH-activated. It is imperative to identify subtypes in conjunction with tumor location when exploring currently available targeted therapy.

AB - Background: Medulloblastoma (MB) comprises of four molecular subtypes, Sonic hedgehog (SHH), Wingless (WNT), Groups 3 and 4. WNT-subtype MBs were found to arise from midline of the brainstem occupying the fourth ventricle while SHH-subtype occupied the cerebellar hemisphere in a small subset of patients. Procedure: We tested this hypothesis in a large cohort of pediatric MBs comprising of all four molecular subtypes. Results: We validated in the first comprehensive analysis of tumor location of 60 human MBs representative of the four molecular subtypes, that hemispheric tumors are significantly associated with SHH-subtype MBs while midline tumors with WNT-subtype, Group 3 and 4 MBs (P<0.001). Nearly half of SHH-subtype MBs were midline. Conclusions: Tumor location should not be generalized to MB subtypes. SHH-subtype MBs are not exclusively hemispheric and hemispheric MBs are not always SHH-activated. It is imperative to identify subtypes in conjunction with tumor location when exploring currently available targeted therapy.

KW - Medulloblastoma

KW - Molecular subtypes

KW - Pediatric

KW - Tumor location

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Implications of tumor location on subtypes of medulloblastoma

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