Implications of Look AHEAD for clinical trials and clinical practice

Rena R. Wing, Paula Bolin, Frederick L. Brancati, George A. Bray, Jeanne M. Clark, Mace Coday, Richard S. Crow, Jeffrey M. Curtis, Caitlin M. Egan, Mark A. Espeland, Mary Evans, John P. Foreyt, Siran Ghazarian, Edward W. Gregg, Barbara Harrison, Helen P. Hazuda, James O. Hill, Edward S. Horton, Van S. Hubbard, John M. JakicicRobert W. Jeffery, Karen C. Johnson, Steven E. Kahn, Abbas E. Kitabchi, William C. Knowler, Cora E. Lewis, Maschak Carey Barbara, Maria G. Montez, Anne Murillo, David M. Nathan, Jennifer Patricio, Anne Peters, Pi Sunyer Xavier, Henry Pownall, David Reboussin, Judith G. Regensteiner, Amy D. Rickman, Donna H. Ryan, Monika Safford, Thomas A. Wadden, Lynne E. Wagenknecht, Delia S. West, David F. Williamson, Susan Z. Yanovski, L. Brancati, Lee Swartzc, Jeanne Charleston, Lawrence Cheskin, Kerry Stewart, Richard Rubin, Jean Arceci, Susanne Danus, David Bolen, Danielle Diggins, Sara Evans, Mia Johnson, Joyce Lambert, Sarah Longenecker, Kathy Michalski, Dawn Jiggetts, Chanchai Sapun, Maria Sowers, Kathy Tyler, Allison Strate, Frank L. Greenway, Donald Williamson, Timothy Church, Catherine Champagne, Valerie Myers, Jennifer Arceneaux, Kristi Rau, Michelle Begnaud, Barbara Cerniauskas, Crystal Duncan, Helen Guay, Carolyn Johnson, Lisa Jones, Kim Landry, Missy Lingle, Jennifer Perault, Cindy Puckett, Marisa Smith, Lauren Cox, Monica Lockett, Sheikilya Thomas, Stephen Glasser, Vicki DiLillo, Charlotte Bragg, Amy Dobelstein, Sara Hannum, Anne Hubbell, Jane King, Lavallade DeLee, Andre Morgan, L. Christie Oden, Janet Wallace, Cathy Roche, Jackie Roche, Janet Turman, Enrico Cagliero, Kathryn Hayward, Heather Turgeon, Valerie Goldman, Linda Delahanty, Ellen Anderson, Laurie Bissett, Virginia Harlan, Theresa Michel, Mary Larkin, Christine Stevens, Sharon D. Jackson, Osama Hamdy, A. Enrique Caballero, Sarah Bain, Elizabeth Bovaird, Barbara Fargnoli, Jeanne Spellman, Kari Galuski, Goebel Fabbri Ann, Lori Lambert, Sarah Ledbury, Maureen Malloy, Kerry Ovalle, George Blackburn, Christos Mantzoros, Ann McNamara, Kristina Spellman, Marsha Miller, Holly Wyatt, B. Van Dorsten, Judith Regensteiner, Debbie Bochert, Ligia Coelho, Paulette Cohrs, Susan Green, April Hamilton, Jere Hamilton, Eugene Leshchinskiy, Loretta Rome, Terra Thompson, Kirstie Craul, Cecilia Wang, Rebecca S. Reeves, Molly Gee, Ashok Balasubramanyam, Huang Chu-Chen, Peter Jones, Michele Burrington, Clark C. Gardner, Sharon Griggs, Michelle Hamilton, Veronica Holley, Sarah Lee, Lane L. Liscum, Susan Cantu-Lumbreras, Julieta Palencia, Jennifer Schmidt, Jayne Thomas, Carolyn White, Carolyn Gresham, Lynne Lichtermann, J. Lee Taylor, Beate Griffin, Donna Valenski, Ebenezer Nyenwe, Helen Lambeth, Moana Mosby, Amy Brewer, Debra Clark, Andrea Crisler, Gracie Cunningham, Debra Force, Donna Green, Robert Kores, Renate Rosenthal, Elizabeth Smith, Tricia Skarphol, Carolyn Thorson, John P. Bantle, J. Bruce Redmon, Kerrin Brelje, Carolyne Campbell, Lisa Hoelscher, Melanie Jaeb, Donna LaJames, Patti Laqua, Vicki A. Maddy, Therese Ockenden, Birgitta I. Rice, Ann D. Tucker, Susan S. Voeller, Cara Walcheck, Pi Sunyer Xavier, Carmen Pal, Lynn Allen, Janet Crane, Lolline Chong, Diane Hirsch, Anne A. Holowaty, Michelle Horowitz, Maschak Carey Barbara, Robert I. Berkowitz, Seth Braunstein, Gary Foster, Henry Glick, Shiriki Kumanyika, Stanley S. Schwartz, Yuliis Bell, Raymond Carvajal, Helen Chomentowski, Renee Davenport, Anthony Fabricatore, Lucy Faulconbridge, Louise Hesson, Nayyar Iqbal, Robert Kuehnel, Patricia Lipschutz, Monica Mullen, David E. Kelley, Jacqueline Wesche-Thobaben, Lewis H. Kuller, Andrea Kriska, Lin Ewing, Mary Korytkowski, Daniel Edmundowicz, Rose Salata, Rebecca Danchenko, Tammy DeBruce, Barbara Elnyczky, David O. Garcia, Patricia H. Harper, Susan Harrier, Dianne Heidingsfelder, Diane Ives, Juliet Mancino, Lisa Martich, Tracey Y. Murray, Karen Quirin, Joan R. Ritchea, Susan Copelli, Renee Bright, Vincent Pera, John Jakicic, Deborah Tate, Amy Gorin, Kara Gallagher, Amy Bach, Barbara Bancroft, Anna Bertorelli, Richard Carey, Tatum Charron, Heather Chenot, Chula Maguire Kimberley, Pamela Coward, Lisa Cronkite, Julie Currin, Maureen Daly, Caitlin Egan, Erica Ferguson, Linda Foss, Jennifer Gauvin, Don Kieffer, Lauren Lessard, Deborah Maier, J. P. Massaro, Tammy Monk, Rob Nicholson, Erin Patterson, Suzanne Phelan, Hollie Raynor, Douglas Raynor, Natalie Robinson, Deborah Robles, Jane Tavares, Steven M. Haffner, Carlos Lorenzo, Charles F. Coleman, Domingo Granado, Kathy Hathaway, Carlos C. Isaac, Nora Ramirez, Robert Knopp, Edward Lipkin, Dace Trence, Elaine Tsai, Basma Fattaleh, Diane Greenberg, Brenda Montgomery, Morgan Taggart Ivy, Ann A. Richmond, Jolanta Socha, April Thomas, Alan Wesley, Diane Wheeler, Tina Killean, Cathy Manus, Jonathan Krakoff, Sara Michaels, Paul Bloomquist, Peter H. Bennett, Bernadita Fallis, Diane F. Hollowbreast, Ruby Johnson, Maria Meacham, Christina Morris, Julie Nelson, Carol Percy, Patricia Poorthunder, Sandra Sangster, Leigh A. Shovestull, Miranda Smart, Janelia Smiley, Teddy Thomas, Katie Toledo, Elizabeth Beale, Kati Konersman, Quintero Varela Brenda, Edgar Ramirez, Gabriela Rios, Gabriela Rodriguez, Valerie Ruelas, Serafin Dokhan Sara, Martha Walker, Judy L. Bahnson, W. Jack Rejeski, Alain G. Bertoni, Wei Lang, Michael S. Lawlor, David Lefkowitz, Gary D. Miller, Patrick S. Reynolds, Paul M. Ribisl, Mara Vitolins, Daniel Beavers, Haiying Chen, Dalane Kitzman, Lawrence M. Friedman, Ron Prineas, Tandaw Samdarshi, Kathy M. Dotson, Amelia Hodges, Limprevil Divers Dominique, Karen Wall, Carrie C. Williams, Andrea Anderson, Jerry M. Barnes, Mary Barr, Tara D. Beckner, Cralen Davis, Valle Fagan Thania Del, Tamika Earl, Melanie Franks, Candace Goode, Jason Griffin, Lea Harvin, Mary A. Hontz, Sarah A. Gaussoin, Don G. Hire, Patricia Hogan, Mark King, Kathy Lane, Rebecca H. Neiberg, Julia T. Rushing, Effoe E. Sammah, Michael P. Walkup, Terri Windham, Michael Nevitt, Ann Schwartz, John Shepherd, Michaela Rahorst, Lisa Palermo, Susan Ewing, Cynthia Hayashi, Jason Maeda, Santica M. Marcovina, Jessica Hurting, John J. Albers, Vinod Gaur, Elsayed Z. Soliman, Zhu Ming Zhang, Hensley Susan, Julie Hu, Lisa Keasler, Yabing Li, Mayer Davis Elizabeth, Robert Moran, Richard Foushee, Nancy J. Hall, Barbara Harrison, S. Cooper, Peter Kaufman, Mario Stylianou, Ping Zhang

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

Look AHEAD (Action for Health in Diabetes) was a randomized clinical trial designed to examine the long-term health effects of weight loss in overweight and obese individuals with type 2 diabetes. The primary result was that the incidence of cardiovascular events over a median follow-up of 9.6 years was not reduced in the Intensive Lifestyle Group relative to the control group. This finding is discussed, with emphasis on its implications for design of trials and clinical treatment of obese persons with type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)1183-1191
Number of pages9
JournalDiabetes, Obesity and Metabolism
Volume16
Issue number12
DOIs
StatePublished - Dec 1 2014

Keywords

  • Cardiovascular disease
  • Dietary intervention
  • Type 2 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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