TY - JOUR
T1 - Implementation of Clinical Decision Support on Emergency Department Delivery of Human Rabies Immune Globulin
AU - Yuan, Fangzheng
AU - Iso, Tomona
AU - Rizk, Elsie
AU - Saldana, R. Benjamin
AU - Tran, Anh Thu
AU - Nguyen, Ngoc Anh A.
AU - Boyareddigari, Prasanth R.
AU - Espino, Daniela
AU - Swan, Joshua T.
N1 - Funding Information:
Funding/Support: Under the direction of principal investigator Dr Swan, this research was supported by research grants from Grifols Shared Services North America Inc, which manufactures and sells human rabies immune globulin in the US, and VigiLanz Corporation. This article was supported by the John F. Jr and Carolyn Bookout Presidential Distinguished Chair fund at the Houston Methodist Hospital Foundation.
Publisher Copyright:
© 2022 American Medical Association. All rights reserved.
PY - 2022/6/21
Y1 - 2022/6/21
N2 - IMPORTANCE: Fatal human rabies infections can be prevented through appropriate rabies postexposure prophylaxis (PEP). Errors in patient selection and administration of human rabies immune globulin in the emergency department (ED) setting were identified in a previous study of rabies PEP administration.OBJECTIVE: To test the a priori hypothesis that implementation of a rabies PEP bundle in the ED would improve full adherence to 6 human rabies immune globulin quality indicators compared with preimplementation controls.DESIGN, SETTING, AND PARTICIPANTS: This quality improvement study was conducted in 15 EDs in a US multihospital health system. Patients who received human rabies immune globulin or rabies vaccine in the ED from January 2015 to June 2018 were included in the preimplementation control group and from December 2019 to November 2020 were included in the postimplementation intervention group. Data were analyzed in January 2021.EXPOSURE: The PEP bundle was implemented in December 2019 and consisted of electronic health record enhancements, including clinical decision support, ED staff education, and patient education.MAIN OUTCOMES AND MEASURES: Full adherence to 6 human rabies immune globulin quality indicators: patient selection, dose, timing, infiltration into wounds, administration distant from rabies vaccine site, and administration that avoids the buttock.RESULTS: The study included 324 patients; 254 patients were in preimplementation group (mean [SD] age, 39 [21] years; 135 [53%] women) and 70 in the postimplementation group (mean [SD] age, 38 [19] years; 33 [47%] women). Most patients presented to EDs embedded in a community hospital (231 patients [71%]). Full adherence increased from 37% in the preimplementation group to 61% postimplementation (absolute increase, 24%; 95% CI, 11% to 37%; P < .001). Adherence improved for quality indicators for infiltration into wounds (137 of 254 patients [54%] to 50 of 70 patients [71%]; P = .009), administration distant from rabies vaccine site (180 of 254 [71%] to 58 of 70 [83%]; P = .04), and administration that avoids the buttock (168 of 254 [66%] to 58 of 70 [83%]; P = .007). No instances of sciatic nerve injury or compartment syndrome were observed.CONCLUSIONS AND RELEVANCE: In this quality improvement study, implementation of a rabies PEP bundle was associated with improved patient selection and delivery of human rabies immune globulin in EDs across a multihospital health system. Although the bundle included ED staff education and patient discharge education, the observed improvement was likely driven by clinical decision support from the rabies PEP ED order set. Future research should evaluate implementation of this clinical decision support at other health systems.
AB - IMPORTANCE: Fatal human rabies infections can be prevented through appropriate rabies postexposure prophylaxis (PEP). Errors in patient selection and administration of human rabies immune globulin in the emergency department (ED) setting were identified in a previous study of rabies PEP administration.OBJECTIVE: To test the a priori hypothesis that implementation of a rabies PEP bundle in the ED would improve full adherence to 6 human rabies immune globulin quality indicators compared with preimplementation controls.DESIGN, SETTING, AND PARTICIPANTS: This quality improvement study was conducted in 15 EDs in a US multihospital health system. Patients who received human rabies immune globulin or rabies vaccine in the ED from January 2015 to June 2018 were included in the preimplementation control group and from December 2019 to November 2020 were included in the postimplementation intervention group. Data were analyzed in January 2021.EXPOSURE: The PEP bundle was implemented in December 2019 and consisted of electronic health record enhancements, including clinical decision support, ED staff education, and patient education.MAIN OUTCOMES AND MEASURES: Full adherence to 6 human rabies immune globulin quality indicators: patient selection, dose, timing, infiltration into wounds, administration distant from rabies vaccine site, and administration that avoids the buttock.RESULTS: The study included 324 patients; 254 patients were in preimplementation group (mean [SD] age, 39 [21] years; 135 [53%] women) and 70 in the postimplementation group (mean [SD] age, 38 [19] years; 33 [47%] women). Most patients presented to EDs embedded in a community hospital (231 patients [71%]). Full adherence increased from 37% in the preimplementation group to 61% postimplementation (absolute increase, 24%; 95% CI, 11% to 37%; P < .001). Adherence improved for quality indicators for infiltration into wounds (137 of 254 patients [54%] to 50 of 70 patients [71%]; P = .009), administration distant from rabies vaccine site (180 of 254 [71%] to 58 of 70 [83%]; P = .04), and administration that avoids the buttock (168 of 254 [66%] to 58 of 70 [83%]; P = .007). No instances of sciatic nerve injury or compartment syndrome were observed.CONCLUSIONS AND RELEVANCE: In this quality improvement study, implementation of a rabies PEP bundle was associated with improved patient selection and delivery of human rabies immune globulin in EDs across a multihospital health system. Although the bundle included ED staff education and patient discharge education, the observed improvement was likely driven by clinical decision support from the rabies PEP ED order set. Future research should evaluate implementation of this clinical decision support at other health systems.
KW - Adult
KW - Decision Support Systems, Clinical
KW - Emergency Service, Hospital
KW - Female
KW - Humans
KW - Immunoglobulins/therapeutic use
KW - Immunologic Factors
KW - Male
KW - Rabies/prevention & control
KW - Rabies Vaccines/therapeutic use
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U2 - 10.1001/jamanetworkopen.2022.16631
DO - 10.1001/jamanetworkopen.2022.16631
M3 - Article
C2 - 35727583
AN - SCOPUS:85132272750
SN - 2574-3805
VL - 5
SP - E2216631
JO - JAMA Network Open
JF - JAMA Network Open
IS - 6
ER -