TY - JOUR
T1 - Impaired functional default mode network in patients with mild neurological Wilson's disease
AU - Han, Yongsheng
AU - Cheng, Hewei
AU - Toledo, Jon B.
AU - Wang, Xun
AU - Li, Bo
AU - Han, Yongzhu
AU - Wang, Kai
AU - Fan, Yong
N1 - Funding Information:
This work was supported by the National Basic Research Program of China [grant number 2015CB856404 ], the Natural Science Foundation of China [grant numbers 81271514 , 61473296 ], the Clinical Research Key Project of Anhui University of Chinese Medicine [grant number 2014lckf02006 ], and the Anhui Provincial Science and Technology Project [grant number 15011d04009 ].
Publisher Copyright:
© 2016 Elsevier Ltd
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Wilson's disease (WD) is an autosomal recessive metabolic disorder characterized by cognitive, psychiatric and motor signs and symptoms that are associated with structural and pathological brain abnormalities, in addition to liver changes. However, functional brain connectivity pattern of WD patients remains largely unknown. In the present study, we investigated functional brain connectivity pattern of WD patients using resting state functional magnetic resonance imaging. Particularly, we studied default mode network (DMN) using posterior cingulate cortex (PCC) based seed functional connectivity analysis and graph theoretic functional brain network analysis tools, and investigated the relationship between the DMN's functional connectivity pattern of WD patients and their attention functions examined using the attention network test (ANT). Our results demonstrated that WD patients had altered DMN's functional connectivity and lower local and global network efficiency compared with normal controls (NCs). In addition, the functional connectivity between left inferior temporal cortex and right lateral parietal cortex was correlated with altering function, one of the attention functions, across WD and NC subjects. These findings indicated that the DMN's functional connectivity was altered in WD patients, which might be correlated with their attention dysfunction.
AB - Wilson's disease (WD) is an autosomal recessive metabolic disorder characterized by cognitive, psychiatric and motor signs and symptoms that are associated with structural and pathological brain abnormalities, in addition to liver changes. However, functional brain connectivity pattern of WD patients remains largely unknown. In the present study, we investigated functional brain connectivity pattern of WD patients using resting state functional magnetic resonance imaging. Particularly, we studied default mode network (DMN) using posterior cingulate cortex (PCC) based seed functional connectivity analysis and graph theoretic functional brain network analysis tools, and investigated the relationship between the DMN's functional connectivity pattern of WD patients and their attention functions examined using the attention network test (ANT). Our results demonstrated that WD patients had altered DMN's functional connectivity and lower local and global network efficiency compared with normal controls (NCs). In addition, the functional connectivity between left inferior temporal cortex and right lateral parietal cortex was correlated with altering function, one of the attention functions, across WD and NC subjects. These findings indicated that the DMN's functional connectivity was altered in WD patients, which might be correlated with their attention dysfunction.
KW - Alerting efficiency
KW - Default mode network
KW - Functional connectivity
KW - Posterior cingulate cortex
KW - Wilson's disease
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U2 - 10.1016/j.parkreldis.2016.06.018
DO - 10.1016/j.parkreldis.2016.06.018
M3 - Article
C2 - 27372239
AN - SCOPUS:84977661200
SN - 1353-8020
VL - 30
SP - 46
EP - 51
JO - Parkinsonism and Related Disorders
JF - Parkinsonism and Related Disorders
ER -