Impact of social determinants of health on DNA methylation

José F. Herrera-Moreno; Aurora E. Rojas-García; Irma M. Medina-Díaz; Yael Y. Bernal-Hernández; Cyndia A. González-Arias; Briscia S. Barrón-Vivanco; Kenneth S. Ramos

doi:10.1016/B978-0-12-824010-6.00017-4

Impact of social determinants of health on DNA methylation

José F. Herrera-Moreno, Aurora E. Rojas-García, Irma M. Medina-Díaz, Yael Y. Bernal-Hernández, Cyndia A. González-Arias, Briscia S. Barrón-Vivanco, Kenneth S. Ramos

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Social determinants of health (SDOH) describe the impact of conditions in which people are born, grow, live, learn, work, play, worship, and age on health. Different studies have associated SDOH with alterations at the hormonal and cellular levels, and with epigenetic modifications such as DNA methylation (DNAm), that alter homeostasis. The aim is to review the influence of SDOH on DNAm, focusing on the role of sociodemographic characteristics, socioeconomic status (SES), nutritional status, physical activity, environmental neighborhood exposures, toxicant exposures, social, and economic environment, adverse childhood events, emotional stress throughout life, social inequality, violence, crime, genocide, and racism.

Original language	English (US)
Title of host publication	Comprehensive Precision Medicine, First Edition, Volume 1-2
Publisher	Elsevier
Pages	394-412
Number of pages	19
Volume	1
ISBN (Electronic)	9780128240106
DOIs	https://doi.org/10.1016/B978-0-12-824010-6.00017-4
State	Published - 2024

Keywords

Aging
DNA methylation
Early-life adversity
Environmental epigenetics
Epigenetic age
Neighborhood exposures
Physical toxicants
SES
Social epigenetics/epigenomics
Trauma exposure

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)

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10.1016/B978-0-12-824010-6.00017-4

Cite this

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title = "Impact of social determinants of health on DNA methylation",

abstract = "Social determinants of health (SDOH) describe the impact of conditions in which people are born, grow, live, learn, work, play, worship, and age on health. Different studies have associated SDOH with alterations at the hormonal and cellular levels, and with epigenetic modifications such as DNA methylation (DNAm), that alter homeostasis. The aim is to review the influence of SDOH on DNAm, focusing on the role of sociodemographic characteristics, socioeconomic status (SES), nutritional status, physical activity, environmental neighborhood exposures, toxicant exposures, social, and economic environment, adverse childhood events, emotional stress throughout life, social inequality, violence, crime, genocide, and racism.",

keywords = "Aging, DNA methylation, Early-life adversity, Environmental epigenetics, Epigenetic age, Neighborhood exposures, Physical toxicants, SES, Social epigenetics/epigenomics, Trauma exposure",

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doi = "10.1016/B978-0-12-824010-6.00017-4",

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T1 - Impact of social determinants of health on DNA methylation

AU - Herrera-Moreno, José F.

AU - Rojas-García, Aurora E.

AU - Medina-Díaz, Irma M.

AU - Bernal-Hernández, Yael Y.

AU - González-Arias, Cyndia A.

AU - Barrón-Vivanco, Briscia S.

AU - Ramos, Kenneth S.

PY - 2024

Y1 - 2024

N2 - Social determinants of health (SDOH) describe the impact of conditions in which people are born, grow, live, learn, work, play, worship, and age on health. Different studies have associated SDOH with alterations at the hormonal and cellular levels, and with epigenetic modifications such as DNA methylation (DNAm), that alter homeostasis. The aim is to review the influence of SDOH on DNAm, focusing on the role of sociodemographic characteristics, socioeconomic status (SES), nutritional status, physical activity, environmental neighborhood exposures, toxicant exposures, social, and economic environment, adverse childhood events, emotional stress throughout life, social inequality, violence, crime, genocide, and racism.

AB - Social determinants of health (SDOH) describe the impact of conditions in which people are born, grow, live, learn, work, play, worship, and age on health. Different studies have associated SDOH with alterations at the hormonal and cellular levels, and with epigenetic modifications such as DNA methylation (DNAm), that alter homeostasis. The aim is to review the influence of SDOH on DNAm, focusing on the role of sociodemographic characteristics, socioeconomic status (SES), nutritional status, physical activity, environmental neighborhood exposures, toxicant exposures, social, and economic environment, adverse childhood events, emotional stress throughout life, social inequality, violence, crime, genocide, and racism.

KW - Aging

KW - DNA methylation

KW - Early-life adversity

KW - Environmental epigenetics

KW - Epigenetic age

KW - Neighborhood exposures

KW - Physical toxicants

KW - SES

KW - Social epigenetics/epigenomics

KW - Trauma exposure

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M3 - Chapter

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VL - 1

SP - 394

EP - 412

BT - Comprehensive Precision Medicine, First Edition, Volume 1-2

PB - Elsevier

ER -

Impact of social determinants of health on DNA methylation

Abstract

Keywords

ASJC Scopus subject areas

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