Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region

Isabel Rodriguez-Barraquer, Federico Costa, Eduardo J.M. Nascimento, Nivison Nery Júnior, Priscila M.S. Castanha, Gielson Almeida Sacramento, Jaqueline Cruz, Mayara Carvalho, Daiana De Olivera, José E. Hagan, Haritha Adhikarla, Elsio A. Wunder, Danilo F. Coêlho, Sasha R. Azar, Shannan L. Rossi, Nikos Vasilakis, Scott C. Weaver, Guilherme S. Ribeiro, Angel Balmaseda, Eva HarrisMaurício L. Nogueira, Mitermayer G. Reis, Ernesto T.A. Marques, Derek A.T. Cummings, Albert I. Ko

    Research output: Contribution to journalArticlepeer-review

    185 Scopus citations


    The clinical outcomes associated with Zika virus (ZIKV) in the Americas have been well documented, but other aspects of the pandemic, such as attack rates and risk factors, are poorly understood. We prospectively followed a cohort of 1453 urban residents in Salvador, Brazil, and, using an assay that measured immunoglobulin G3 (IgG3) responses against ZIKV NS1 antigen, we estimated that 73% of individuals were infected during the 2015 outbreak. Attack rates were spatially heterogeneous, varying by a factor of 3 within a community spanning 0.17 square kilometers. Preexisting high antibody titers to dengue virus were associated with reduced risk of ZIKV infection and symptoms. The landscape of ZIKV immunity that now exists may affect the risk for future transmission.

    Original languageEnglish (US)
    Pages (from-to)607-610
    Number of pages4
    Issue number6427
    StatePublished - Feb 8 2019

    ASJC Scopus subject areas

    • General


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