Impact of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls on human and environmental health, with special emphasis on application of the toxic equivalency factor concept

Ulf G. Ahlborg; Abraham Brouwer; Marilyn A. Fingerhut; Joseph L. Jacobson; Sandra W. Jacobson; Sean W. Kennedy; Antonius A.F. Kettrup; Jan H. Koeman; Hermann Poiger; Christoffer Rappe; Stephen H. Safe; Richard F. Seegal; Tuomisto Jouko Tuomisto; Martin van den Berg

doi:10.1016/0926-6917(92)90029-C

Impact of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls on human and environmental health, with special emphasis on application of the toxic equivalency factor concept

Ulf G. Ahlborg, Abraham Brouwer, Marilyn A. Fingerhut, Joseph L. Jacobson, Sandra W. Jacobson, Sean W. Kennedy, Antonius A.F. Kettrup, Jan H. Koeman, Hermann Poiger, Christoffer Rappe, Stephen H. Safe, Richard F. Seegal, Tuomisto Jouko Tuomisto, Martin van den Berg

Research output: Contribution to journal › Article

187 Scopus citations

Abstract

A scientific evaluation was made of the mechanisms of action of polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls. Distinction is made between the aryl-hydrocarbon (Ah) receptor-mediated and non-Ah receptor-mediated toxic responses. Special attention is paid to the applicability of the toxic equivalency factor (TEF) concept.

Original language	English (US)
Pages (from-to)	179-199
Number of pages	21
Journal	European Journal of Pharmacology: Environmental Toxicology and
Volume	228
Issue number	4
DOIs	https://doi.org/10.1016/0926-6917(92)90029-C
State	Published - Dec 1 1992

Keywords

(PCBs)
(PCDDs)
(PCDFs)
(TEF)
Ah (aryl-hydrocarbon)-mediated effects
Ah receptors
Carcinogenicity
Endocrine responses
Kinetics
Metabolism
Neurobehavioural responses
Non-Ah (aryl-hydrocarbon)-mediated effects
Polychlorinated biphenyls
Polychlorinated dibenzo-p-dioxins
Polychlorinated dibenzofurans
Risk management
Species differences
Toxic equivalency factor

ASJC Scopus subject areas

Toxicology
Pharmacology
Pollution

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10.1016/0926-6917(92)90029-C

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Ahlborg, U. G., Brouwer, A., Fingerhut, M. A., Jacobson, J. L., Jacobson, S. W., Kennedy, S. W., Kettrup, A. A. F., Koeman, J. H., Poiger, H., Rappe, C., Safe, S. H., Seegal, R. F., Jouko Tuomisto, T., & van den Berg, M. (1992). Impact of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls on human and environmental health, with special emphasis on application of the toxic equivalency factor concept. European Journal of Pharmacology: Environmental Toxicology and, 228(4), 179-199. https://doi.org/10.1016/0926-6917(92)90029-C

Impact of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls on human and environmental health, with special emphasis on application of the toxic equivalency factor concept. / Ahlborg, Ulf G.; Brouwer, Abraham; Fingerhut, Marilyn A.; Jacobson, Joseph L.; Jacobson, Sandra W.; Kennedy, Sean W.; Kettrup, Antonius A.F.; Koeman, Jan H.; Poiger, Hermann; Rappe, Christoffer; Safe, Stephen H.; Seegal, Richard F.; Jouko Tuomisto, Tuomisto; van den Berg, Martin.

In: European Journal of Pharmacology: Environmental Toxicology and, Vol. 228, No. 4, 01.12.1992, p. 179-199.

Research output: Contribution to journal › Article

Ahlborg, UG, Brouwer, A, Fingerhut, MA, Jacobson, JL, Jacobson, SW, Kennedy, SW, Kettrup, AAF, Koeman, JH, Poiger, H, Rappe, C, Safe, SH, Seegal, RF, Jouko Tuomisto, T & van den Berg, M 1992, 'Impact of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls on human and environmental health, with special emphasis on application of the toxic equivalency factor concept', European Journal of Pharmacology: Environmental Toxicology and, vol. 228, no. 4, pp. 179-199. https://doi.org/10.1016/0926-6917(92)90029-C

Ahlborg UG, Brouwer A, Fingerhut MA, Jacobson JL, Jacobson SW, Kennedy SW et al. Impact of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls on human and environmental health, with special emphasis on application of the toxic equivalency factor concept. European Journal of Pharmacology: Environmental Toxicology and. 1992 Dec 1;228(4):179-199. https://doi.org/10.1016/0926-6917(92)90029-C

Ahlborg, Ulf G. ; Brouwer, Abraham ; Fingerhut, Marilyn A. ; Jacobson, Joseph L. ; Jacobson, Sandra W. ; Kennedy, Sean W. ; Kettrup, Antonius A.F. ; Koeman, Jan H. ; Poiger, Hermann ; Rappe, Christoffer ; Safe, Stephen H. ; Seegal, Richard F. ; Jouko Tuomisto, Tuomisto ; van den Berg, Martin. / Impact of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls on human and environmental health, with special emphasis on application of the toxic equivalency factor concept. In: European Journal of Pharmacology: Environmental Toxicology and. 1992 ; Vol. 228, No. 4. pp. 179-199.

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abstract = "A scientific evaluation was made of the mechanisms of action of polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls. Distinction is made between the aryl-hydrocarbon (Ah) receptor-mediated and non-Ah receptor-mediated toxic responses. Special attention is paid to the applicability of the toxic equivalency factor (TEF) concept.",

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AU - Jacobson, Joseph L.

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AU - Poiger, Hermann

AU - Rappe, Christoffer

AU - Safe, Stephen H.

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