Abstract
A scientific evaluation was made of the mechanisms of action of polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls. Distinction is made between the aryl-hydrocarbon (Ah) receptor-mediated and non-Ah receptor-mediated toxic responses. Special attention is paid to the applicability of the toxic equivalency factor (TEF) concept.
Original language | English (US) |
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Pages (from-to) | 179-199 |
Number of pages | 21 |
Journal | European Journal of Pharmacology: Environmental Toxicology and |
Volume | 228 |
Issue number | 4 |
DOIs | |
State | Published - Dec 1 1992 |
Keywords
- (PCBs)
- (PCDDs)
- (PCDFs)
- (TEF)
- Ah (aryl-hydrocarbon)-mediated effects
- Ah receptors
- Carcinogenicity
- Endocrine responses
- Kinetics
- Metabolism
- Neurobehavioural responses
- Non-Ah (aryl-hydrocarbon)-mediated effects
- Polychlorinated biphenyls
- Polychlorinated dibenzo-p-dioxins
- Polychlorinated dibenzofurans
- Risk management
- Species differences
- Toxic equivalency factor
ASJC Scopus subject areas
- Toxicology
- Pharmacology
- Pollution