Impact of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls on human and environmental health, with special emphasis on application of the toxic equivalency factor concept

Ulf G. Ahlborg; Abraham Brouwer; Marilyn A. Fingerhut; Joseph L. Jacobson; Sandra W. Jacobson; Sean W. Kennedy; Antonius A.F. Kettrup; Jan H. Koeman; Hermann Poiger; Christoffer Rappe; Stephen H. Safe; Richard F. Seegal; Tuomisto Jouko Tuomisto; Martin van den Berg

doi:10.1016/0926-6917(92)90029-C

Impact of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls on human and environmental health, with special emphasis on application of the toxic equivalency factor concept

Ulf G. Ahlborg, Abraham Brouwer, Marilyn A. Fingerhut, Joseph L. Jacobson, Sandra W. Jacobson, Sean W. Kennedy, Antonius A.F. Kettrup, Jan H. Koeman, Hermann Poiger, Christoffer Rappe, Stephen H. Safe, Richard F. Seegal, Tuomisto Jouko Tuomisto, Martin van den Berg

Research output: Contribution to journal › Article › peer-review

207 Scopus citations

Abstract

A scientific evaluation was made of the mechanisms of action of polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls. Distinction is made between the aryl-hydrocarbon (Ah) receptor-mediated and non-Ah receptor-mediated toxic responses. Special attention is paid to the applicability of the toxic equivalency factor (TEF) concept.

Original language	English (US)
Pages (from-to)	179-199
Number of pages	21
Journal	European Journal of Pharmacology: Environmental Toxicology and
Volume	228
Issue number	4
DOIs	https://doi.org/10.1016/0926-6917(92)90029-C
State	Published - Dec 1 1992

Keywords

(PCBs)
(PCDDs)
(PCDFs)
(TEF)
Ah (aryl-hydrocarbon)-mediated effects
Ah receptors
Carcinogenicity
Endocrine responses
Kinetics
Metabolism
Neurobehavioural responses
Non-Ah (aryl-hydrocarbon)-mediated effects
Polychlorinated biphenyls
Polychlorinated dibenzo-p-dioxins
Polychlorinated dibenzofurans
Risk management
Species differences
Toxic equivalency factor

ASJC Scopus subject areas

Toxicology
Pharmacology
Pollution

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10.1016/0926-6917(92)90029-C

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Ahlborg, U. G., Brouwer, A., Fingerhut, M. A., Jacobson, J. L., Jacobson, S. W., Kennedy, S. W., Kettrup, A. A. F., Koeman, J. H., Poiger, H., Rappe, C., Safe, S. H., Seegal, R. F., Jouko Tuomisto, T., & van den Berg, M. (1992). Impact of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls on human and environmental health, with special emphasis on application of the toxic equivalency factor concept. European Journal of Pharmacology: Environmental Toxicology and, 228(4), 179-199. https://doi.org/10.1016/0926-6917(92)90029-C

Impact of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls on human and environmental health, with special emphasis on application of the toxic equivalency factor concept. / Ahlborg, Ulf G.; Brouwer, Abraham; Fingerhut, Marilyn A. et al.
In: European Journal of Pharmacology: Environmental Toxicology and, Vol. 228, No. 4, 01.12.1992, p. 179-199.

Research output: Contribution to journal › Article › peer-review

Ahlborg, UG, Brouwer, A, Fingerhut, MA, Jacobson, JL, Jacobson, SW, Kennedy, SW, Kettrup, AAF, Koeman, JH, Poiger, H, Rappe, C, Safe, SH, Seegal, RF, Jouko Tuomisto, T & van den Berg, M 1992, 'Impact of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls on human and environmental health, with special emphasis on application of the toxic equivalency factor concept', European Journal of Pharmacology: Environmental Toxicology and, vol. 228, no. 4, pp. 179-199. https://doi.org/10.1016/0926-6917(92)90029-C

Ahlborg UG, Brouwer A, Fingerhut MA, Jacobson JL, Jacobson SW, Kennedy SW et al. Impact of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls on human and environmental health, with special emphasis on application of the toxic equivalency factor concept. European Journal of Pharmacology: Environmental Toxicology and. 1992 Dec 1;228(4):179-199. doi: 10.1016/0926-6917(92)90029-C

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abstract = "A scientific evaluation was made of the mechanisms of action of polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls. Distinction is made between the aryl-hydrocarbon (Ah) receptor-mediated and non-Ah receptor-mediated toxic responses. Special attention is paid to the applicability of the toxic equivalency factor (TEF) concept.",

keywords = "(PCBs), (PCDDs), (PCDFs), (TEF), Ah (aryl-hydrocarbon)-mediated effects, Ah receptors, Carcinogenicity, Endocrine responses, Kinetics, Metabolism, Neurobehavioural responses, Non-Ah (aryl-hydrocarbon)-mediated effects, Polychlorinated biphenyls, Polychlorinated dibenzo-p-dioxins, Polychlorinated dibenzofurans, Risk management, Species differences, Toxic equivalency factor",

author = "Ahlborg, {Ulf G.} and Abraham Brouwer and Fingerhut, {Marilyn A.} and Jacobson, {Joseph L.} and Jacobson, {Sandra W.} and Kennedy, {Sean W.} and Kettrup, {Antonius A.F.} and Koeman, {Jan H.} and Hermann Poiger and Christoffer Rappe and Safe, {Stephen H.} and Seegal, {Richard F.} and {Jouko Tuomisto}, Tuomisto and {van den Berg}, Martin",

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AU - Brouwer, Abraham

AU - Fingerhut, Marilyn A.

AU - Jacobson, Joseph L.

AU - Jacobson, Sandra W.

AU - Kennedy, Sean W.

AU - Kettrup, Antonius A.F.

AU - Koeman, Jan H.

AU - Poiger, Hermann

AU - Rappe, Christoffer

AU - Safe, Stephen H.

AU - Seegal, Richard F.

AU - Jouko Tuomisto, Tuomisto

AU - van den Berg, Martin

N1 - Funding Information: Wolfe, W.H., J.E. Michalek and J.C. Miner, 1991, An epidemiologic investigation of health effects in Air Force personnel following exposure to herbicides, in: Air Force Health Study Vols. I-IX, Analysis of 1987 Examination Results, Contract No. F41689-85-D-0010, SAIC Project No. 1-813-X4-195/254/437/011/942/943.

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N2 - A scientific evaluation was made of the mechanisms of action of polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls. Distinction is made between the aryl-hydrocarbon (Ah) receptor-mediated and non-Ah receptor-mediated toxic responses. Special attention is paid to the applicability of the toxic equivalency factor (TEF) concept.

AB - A scientific evaluation was made of the mechanisms of action of polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls. Distinction is made between the aryl-hydrocarbon (Ah) receptor-mediated and non-Ah receptor-mediated toxic responses. Special attention is paid to the applicability of the toxic equivalency factor (TEF) concept.

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KW - (PCDDs)

KW - (PCDFs)

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KW - Ah receptors

KW - Carcinogenicity

KW - Endocrine responses

KW - Kinetics

KW - Metabolism

KW - Neurobehavioural responses

KW - Non-Ah (aryl-hydrocarbon)-mediated effects

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KW - Polychlorinated dibenzo-p-dioxins

KW - Polychlorinated dibenzofurans

KW - Risk management

KW - Species differences

KW - Toxic equivalency factor

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Impact of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls on human and environmental health, with special emphasis on application of the toxic equivalency factor concept

Abstract

Keywords

ASJC Scopus subject areas

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