Impact of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls on human and environmental health, with special emphasis on application of the toxic equivalency factor concept

Ulf G. Ahlborg, Abraham Brouwer, Marilyn A. Fingerhut, Joseph L. Jacobson, Sandra W. Jacobson, Sean W. Kennedy, Antonius A.F. Kettrup, Jan H. Koeman, Hermann Poiger, Christoffer Rappe, Stephen H. Safe, Richard F. Seegal, Tuomisto Jouko Tuomisto, Martin van den Berg

Research output: Contribution to journalArticle

187 Scopus citations

Abstract

A scientific evaluation was made of the mechanisms of action of polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls. Distinction is made between the aryl-hydrocarbon (Ah) receptor-mediated and non-Ah receptor-mediated toxic responses. Special attention is paid to the applicability of the toxic equivalency factor (TEF) concept.

Original languageEnglish (US)
Pages (from-to)179-199
Number of pages21
JournalEuropean Journal of Pharmacology: Environmental Toxicology and
Volume228
Issue number4
DOIs
StatePublished - Dec 1 1992

Keywords

  • (PCBs)
  • (PCDDs)
  • (PCDFs)
  • (TEF)
  • Ah (aryl-hydrocarbon)-mediated effects
  • Ah receptors
  • Carcinogenicity
  • Endocrine responses
  • Kinetics
  • Metabolism
  • Neurobehavioural responses
  • Non-Ah (aryl-hydrocarbon)-mediated effects
  • Polychlorinated biphenyls
  • Polychlorinated dibenzo-p-dioxins
  • Polychlorinated dibenzofurans
  • Risk management
  • Species differences
  • Toxic equivalency factor

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Pollution

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