Impact of 18F-FDG PET/CT on the management of adrenocortical carcinoma: analysis of 106 patients

Satoshi Takeuchi, Aparna Balachandran, Mouhammed Amir Habra, Alexandria T. Phan, Roland L. Bassett, Homer A. Macapinlac, Hubert H. Chuang

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Purpose: Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy. Limited data are available about on value of 18F-FDG PET/CT in ACC. We evaluated the impact of PET/CT on the management of ACC.

Methods: We performed a retrospective review in patients with ACC who had undergone PET/CT. The impact of PET/CT on the management plan was evaluated by comparing the findings on PET/CT to the findings on contrast-enhanced CT. The sensitivity, specificity, and accuracy of each form of imaging were calculated. The correlations between PET/CT parameters, including maximum standardized uptake value (SUVmax), total lesion glycolysis, and decline in SUVmax after chemotherapy, and clinical outcome were evaluated.

Conclusion: PET/CT findings could substantially change the management plan in a small proportion of patients with ACC. Although lesion detection was similar between PET/CT and CT, PET/CT may be preferred for chemotherapeutic response assessment because it may predict response before anatomic changes are detected on CT.

Results: Included in the analysis were 106 patients with 180 PET/CT scans. Of the 106 patients, 7 underwent PET/CT only for initial staging, 84 underwent PET/CT only for restaging, and 15 underwent PET/CT for both initial staging and restaging. PET/CT changed the management plan in 1 of 22 patients (5 %) at initial staging and 9 of 99 patients (9 %) at restaging. In 5 of the patients in whom PET/CT changed the management plan, PET/CT showed response to chemotherapy but contrast-enhanced CT showed stable disease. Sensitivity, specificity, and accuracy were 100 %, 100 %, and 100 % for PET/CT at initial staging; 92.6 %, 100 %, and 96.4 % for CT at initial staging; 98.4 %, 100 %, and 99.5 % for PET/CT at restaging; and 96.8 %, 98.6 %, and 98.0 % for CT at restaging, respectively. No PET/CT parameters were associated with survival at either initial diagnosis or recurrence.

Original languageEnglish (US)
Pages (from-to)2066-2073
Number of pages8
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Issue number11
StatePublished - Nov 2014


  • Adrenocortical carcinoma
  • Impact on management
  • PET/CT
  • Response assessment

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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