Impact of lactobacillus acidophilus supplements on the faecal microflora and soluble faecal bile acids in colon cancer patients

A. Lidbeck, U. Geltner Allinger, K. M. Orrhage, L. Ottova, B. Brismar, Jan-Ake Gustafsson, J. J. Rafter, C. E. Nord

Research output: Contribution to journalArticle

64 Scopus citations

Abstract

The impact of fermented Lactobacillus acidophilus milk on the dietary intake, faecal microflora and faecal bile acids in the aqueous phase was investigated in 14 colon cancer patients. The lactobacillus supplements were given for 6 wk. The number of Escherichia coli decreased in five patients in the colonic microflora, and new colonisation with Klebsiella spp. was observed in six patients. Lactobacilli increased significantly (P < 0.05) in 10 patients. In nine patients several Clostridium spp., isolated before L.acidophilus administration, decreased or disappeared. A 15 per cent decrease in the concentration of total bile acids in the aqueous phase occurred, and an 18 per cent decrease in deoxycholic acid. The wet/dry weight ratio was significantly reduced after 6 wk (P < 0.02). The patients significantly increased their energy (P < 0.05), protein (P < 0.0005) and calcium (P < 00005) intake during the supplementation period while the fat energy percentage decreased significantly (P < 0.005). The results suggest that L.acidophilus had an impact on the faecal microflora. There was also a trend towards a decrease in faecal bile acids in the aqueous phase. The supplementation of the fermented milk seemed to be nutritionally advantageous for the colon cancer patients.

Original languageEnglish (US)
Pages (from-to)81-88
Number of pages8
JournalMicrobial Ecology in Health and Disease
Volume4
Issue number2
DOIs
StatePublished - Jan 1 1991

Keywords

  • Bile acids
  • Colon cancer
  • Dietary survey
  • Intestinal microflora
  • Lactobacillus acidophilus
  • βGlucuronidase

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Fingerprint Dive into the research topics of 'Impact of lactobacillus acidophilus supplements on the faecal microflora and soluble faecal bile acids in colon cancer patients'. Together they form a unique fingerprint.

Cite this