TY - JOUR
T1 - Impact of cellular metabolism on the biological effects of benzo[a]pyrene and related hydrocarbons
AU - Miller, Kimberly P.
AU - Ramos, Kenneth S.
PY - 2001
Y1 - 2001
N2 - Polycyclic aromatic hydrocarbons are ubiquitous contaminants in the environment. Benzo[a]pyrene (BaP). a prototypical member of this class of chemicals, has been extensively studied for its toxic effects in laboratory, animals and human populations. BaP toxicity is often mediated by oxidative metabolism to reactive intermediates that interact with macromolecules leading to alterations in target cell structure and function. More recent evidence suggests that disruption of cellular signaling pathways involved in the regulation of growth and differentiation contribute significantly to the toxicity of BaP and its metabolites. This review summarizes recent advances in our understanding of biological mechanisms of BaP toxicity at the molecular level, and the role of metabolic intermediates in carcinogenesis, atherogenesis, and teratogenesis.
AB - Polycyclic aromatic hydrocarbons are ubiquitous contaminants in the environment. Benzo[a]pyrene (BaP). a prototypical member of this class of chemicals, has been extensively studied for its toxic effects in laboratory, animals and human populations. BaP toxicity is often mediated by oxidative metabolism to reactive intermediates that interact with macromolecules leading to alterations in target cell structure and function. More recent evidence suggests that disruption of cellular signaling pathways involved in the regulation of growth and differentiation contribute significantly to the toxicity of BaP and its metabolites. This review summarizes recent advances in our understanding of biological mechanisms of BaP toxicity at the molecular level, and the role of metabolic intermediates in carcinogenesis, atherogenesis, and teratogenesis.
UR - http://www.scopus.com/inward/record.url?scp=0035120777&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035120777&partnerID=8YFLogxK
U2 - 10.1081/DMR-100000138
DO - 10.1081/DMR-100000138
M3 - Review article
C2 - 11270659
AN - SCOPUS:0035120777
VL - 33
SP - 1
EP - 35
JO - Drug Metabolism Reviews
JF - Drug Metabolism Reviews
SN - 0360-2532
IS - 1
ER -