Impact of autologous blood transfusion after bone marrow harvest on unrelated donor’s health and outcome: a CIBMTR analysis

Nosha Farhadfar; Hemant S. Murthy; Brent R. Logan; Jennifer A. Sees; Mouhab Ayas; Minoo Battiwalla; Amer M. Beitinjaneh; Saurabh Chhabra; Miguel Angel Diaz; Katie Engles; Haydar Frangoul; Siddhartha Ganguly; Usama Gergis; Nayesh R. Kamani; Rammurti T. Kamble; Kimberly A. Kasow; Hillard M. Lazarus; Jane L. Liesveld; Maxim Norkin; Paul V. O’ Donnell; Richard F. Olsson; Susan Rossmann; Bipin N. Savani; Raquel Schears; Sachiko Seo; Melhem M. Solh; Thomas Spitzer; Michele Sugrue; Jean A. Yared; Michael Linenberger; Joseph Schwartz; Michael A. Pulsipher; Nirali N. Shah; Galen E. Switzer; Dennis L. Confer; Bronwen E. Shaw; John R. Wingard

doi:10.1038/s41409-020-0911-8

Impact of autologous blood transfusion after bone marrow harvest on unrelated donor’s health and outcome: a CIBMTR analysis

Nosha Farhadfar, Hemant S. Murthy, Brent R. Logan, Jennifer A. Sees, Mouhab Ayas, Minoo Battiwalla, Amer M. Beitinjaneh, Saurabh Chhabra, Miguel Angel Diaz, Katie Engles, Haydar Frangoul, Siddhartha Ganguly, Usama Gergis, Nayesh R. Kamani, Rammurti T. Kamble, Kimberly A. Kasow, Hillard M. Lazarus, Jane L. Liesveld, Maxim Norkin, Paul V. O’ DonnellRichard F. Olsson, Susan Rossmann, Bipin N. Savani, Raquel Schears, Sachiko Seo, Melhem M. Solh, Thomas Spitzer, Michele Sugrue, Jean A. Yared, Michael Linenberger, Joseph Schwartz, Michael A. Pulsipher, Nirali N. Shah, Galen E. Switzer, Dennis L. Confer, Bronwen E. Shaw, John R. Wingard

Houston Methodist

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Pre-harvest autologous blood collection from bone marrow (BM) donors is performed to meet potential post-operative transfusion needs. This study examines the impact of autologous blood transfusion on BM donor’s health and safety. The study included first-time unrelated BM donors from the United States whose BM harvest was facilitated by the National Marrow Donor Program (NMDP) centers between 2006 and 2017. Examination of 7024 BM donors revealed that 60% received at least one unit of autologous blood. The donors who received autologous blood were older, had lower hemoglobin pre-harvest, underwent longer duration of anesthesia, and higher volume BM harvest. Only donors who underwent high-volume BM harvest, defined as a BM harvest volume >27% of donor’s blood volume, benefited from autologous transfusion. After a high-volume BM harvest, autologous blood transfusion was shown to decrease grade 2 to 4 collection-associated toxicities within 48 h of BM donation (p = 0.010) and shorten the time to donor-reported “complete” recovery from donation-associated symptoms (p < 0.001). Therefore, autologous transfusion could be avoided as support of marrow donation in the majority of unrelated BM donors and should be limited to cases where the planned BM harvest volume is expected to exceed 27% of donor’s blood volume.

Original language	English (US)
Pages (from-to)	2121-2131
Number of pages	11
Journal	Bone Marrow Transplantation
Volume	55
Issue number	11
DOIs	https://doi.org/10.1038/s41409-020-0911-8
State	Published - Nov 1 2020

ASJC Scopus subject areas

Hematology
Transplantation

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10.1038/s41409-020-0911-8

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Farhadfar, N., Murthy, H. S., Logan, B. R., Sees, J. A., Ayas, M., Battiwalla, M., Beitinjaneh, A. M., Chhabra, S., Diaz, M. A., Engles, K., Frangoul, H., Ganguly, S., Gergis, U., Kamani, N. R., Kamble, R. T., Kasow, K. A., Lazarus, H. M., Liesveld, J. L., Norkin, M., ... Wingard, J. R. (2020). Impact of autologous blood transfusion after bone marrow harvest on unrelated donor’s health and outcome: a CIBMTR analysis. Bone Marrow Transplantation, 55(11), 2121-2131. https://doi.org/10.1038/s41409-020-0911-8

Farhadfar, N, Murthy, HS, Logan, BR, Sees, JA, Ayas, M, Battiwalla, M, Beitinjaneh, AM, Chhabra, S, Diaz, MA, Engles, K, Frangoul, H, Ganguly, S, Gergis, U, Kamani, NR, Kamble, RT, Kasow, KA, Lazarus, HM, Liesveld, JL, Norkin, M, O’ Donnell, PV, Olsson, RF, Rossmann, S, Savani, BN, Schears, R, Seo, S, Solh, MM, Spitzer, T, Sugrue, M, Yared, JA, Linenberger, M, Schwartz, J, Pulsipher, MA, Shah, NN, Switzer, GE, Confer, DL, Shaw, BE & Wingard, JR 2020, 'Impact of autologous blood transfusion after bone marrow harvest on unrelated donor’s health and outcome: a CIBMTR analysis', Bone Marrow Transplantation, vol. 55, no. 11, pp. 2121-2131. https://doi.org/10.1038/s41409-020-0911-8

@article{10dbd96bbac54f4eaadb013f73d70b72,

title = "Impact of autologous blood transfusion after bone marrow harvest on unrelated donor{\textquoteright}s health and outcome: a CIBMTR analysis",

abstract = "Pre-harvest autologous blood collection from bone marrow (BM) donors is performed to meet potential post-operative transfusion needs. This study examines the impact of autologous blood transfusion on BM donor{\textquoteright}s health and safety. The study included first-time unrelated BM donors from the United States whose BM harvest was facilitated by the National Marrow Donor Program (NMDP) centers between 2006 and 2017. Examination of 7024 BM donors revealed that 60% received at least one unit of autologous blood. The donors who received autologous blood were older, had lower hemoglobin pre-harvest, underwent longer duration of anesthesia, and higher volume BM harvest. Only donors who underwent high-volume BM harvest, defined as a BM harvest volume >27% of donor{\textquoteright}s blood volume, benefited from autologous transfusion. After a high-volume BM harvest, autologous blood transfusion was shown to decrease grade 2 to 4 collection-associated toxicities within 48 h of BM donation (p = 0.010) and shorten the time to donor-reported “complete” recovery from donation-associated symptoms (p < 0.001). Therefore, autologous transfusion could be avoided as support of marrow donation in the majority of unrelated BM donors and should be limited to cases where the planned BM harvest volume is expected to exceed 27% of donor{\textquoteright}s blood volume.",

author = "Nosha Farhadfar and Murthy, {Hemant S.} and Logan, {Brent R.} and Sees, {Jennifer A.} and Mouhab Ayas and Minoo Battiwalla and Beitinjaneh, {Amer M.} and Saurabh Chhabra and Diaz, {Miguel Angel} and Katie Engles and Haydar Frangoul and Siddhartha Ganguly and Usama Gergis and Kamani, {Nayesh R.} and Kamble, {Rammurti T.} and Kasow, {Kimberly A.} and Lazarus, {Hillard M.} and Liesveld, {Jane L.} and Maxim Norkin and {O{\textquoteright} Donnell}, {Paul V.} and Olsson, {Richard F.} and Susan Rossmann and Savani, {Bipin N.} and Raquel Schears and Sachiko Seo and Solh, {Melhem M.} and Thomas Spitzer and Michele Sugrue and Yared, {Jean A.} and Michael Linenberger and Joseph Schwartz and Pulsipher, {Michael A.} and Shah, {Nirali N.} and Switzer, {Galen E.} and Confer, {Dennis L.} and Shaw, {Bronwen E.} and Wingard, {John R.}",

note = "Publisher Copyright: {\textcopyright} 2020, The Author(s), under exclusive licence to Springer Nature Limited.",

year = "2020",

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doi = "10.1038/s41409-020-0911-8",

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T1 - Impact of autologous blood transfusion after bone marrow harvest on unrelated donor’s health and outcome

T2 - a CIBMTR analysis

AU - Farhadfar, Nosha

AU - Murthy, Hemant S.

AU - Logan, Brent R.

AU - Sees, Jennifer A.

AU - Ayas, Mouhab

AU - Battiwalla, Minoo

AU - Beitinjaneh, Amer M.

AU - Chhabra, Saurabh

AU - Diaz, Miguel Angel

AU - Engles, Katie

AU - Frangoul, Haydar

AU - Ganguly, Siddhartha

AU - Gergis, Usama

AU - Kamani, Nayesh R.

AU - Kamble, Rammurti T.

AU - Kasow, Kimberly A.

AU - Lazarus, Hillard M.

AU - Liesveld, Jane L.

AU - Norkin, Maxim

AU - O’ Donnell, Paul V.

AU - Olsson, Richard F.

AU - Rossmann, Susan

AU - Savani, Bipin N.

AU - Schears, Raquel

AU - Seo, Sachiko

AU - Solh, Melhem M.

AU - Spitzer, Thomas

AU - Sugrue, Michele

AU - Yared, Jean A.

AU - Linenberger, Michael

AU - Schwartz, Joseph

AU - Pulsipher, Michael A.

AU - Shah, Nirali N.

AU - Switzer, Galen E.

AU - Confer, Dennis L.

AU - Shaw, Bronwen E.

AU - Wingard, John R.

PY - 2020/11/1

Y1 - 2020/11/1

N2 - Pre-harvest autologous blood collection from bone marrow (BM) donors is performed to meet potential post-operative transfusion needs. This study examines the impact of autologous blood transfusion on BM donor’s health and safety. The study included first-time unrelated BM donors from the United States whose BM harvest was facilitated by the National Marrow Donor Program (NMDP) centers between 2006 and 2017. Examination of 7024 BM donors revealed that 60% received at least one unit of autologous blood. The donors who received autologous blood were older, had lower hemoglobin pre-harvest, underwent longer duration of anesthesia, and higher volume BM harvest. Only donors who underwent high-volume BM harvest, defined as a BM harvest volume >27% of donor’s blood volume, benefited from autologous transfusion. After a high-volume BM harvest, autologous blood transfusion was shown to decrease grade 2 to 4 collection-associated toxicities within 48 h of BM donation (p = 0.010) and shorten the time to donor-reported “complete” recovery from donation-associated symptoms (p < 0.001). Therefore, autologous transfusion could be avoided as support of marrow donation in the majority of unrelated BM donors and should be limited to cases where the planned BM harvest volume is expected to exceed 27% of donor’s blood volume.

AB - Pre-harvest autologous blood collection from bone marrow (BM) donors is performed to meet potential post-operative transfusion needs. This study examines the impact of autologous blood transfusion on BM donor’s health and safety. The study included first-time unrelated BM donors from the United States whose BM harvest was facilitated by the National Marrow Donor Program (NMDP) centers between 2006 and 2017. Examination of 7024 BM donors revealed that 60% received at least one unit of autologous blood. The donors who received autologous blood were older, had lower hemoglobin pre-harvest, underwent longer duration of anesthesia, and higher volume BM harvest. Only donors who underwent high-volume BM harvest, defined as a BM harvest volume >27% of donor’s blood volume, benefited from autologous transfusion. After a high-volume BM harvest, autologous blood transfusion was shown to decrease grade 2 to 4 collection-associated toxicities within 48 h of BM donation (p = 0.010) and shorten the time to donor-reported “complete” recovery from donation-associated symptoms (p < 0.001). Therefore, autologous transfusion could be avoided as support of marrow donation in the majority of unrelated BM donors and should be limited to cases where the planned BM harvest volume is expected to exceed 27% of donor’s blood volume.

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Impact of autologous blood transfusion after bone marrow harvest on unrelated donor’s health and outcome: a CIBMTR analysis

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