Immunotoxicity derived from manipulating leukocytes with lipid-based nanoparticles

Research output: Contribution to journalReview articlepeer-review

61 Scopus citations

Abstract

Lipid-based nanoparticles (LNPs) such as liposomes, micelles, and hybrid systems (e.g. lipid-polymer) are prominent delivery vehicles that already made an impact on the lives of millions around the globe. A common denominator of all these LNP-based platforms is to deliver drugs into specific tissues or cells in a pathological setting with minimal adverse effects on bystander cells. All these platforms must be compatible to the physiological environment and prevent undesirable interactions with the immune system. Avoiding immune stimulation or suppression is an important consideration when developing new strategies in drug and gene delivery, whereas in adjuvants for vaccine therapies, immune activation is desired. Therefore, profound understanding of how LNPs elicit immune responses is essential for the optimization of these systems for various biomedical applications. Herein, I describe general concepts of the immune system and the interaction of subsets of leukocytes with LNPs. Finally, I detail the different immune toxicities reported and propose ways to manipulate leukocytes' functions using LNPs.

Original languageEnglish (US)
Pages (from-to)1738-1748
Number of pages11
JournalAdvanced Drug Delivery Reviews
Volume64
Issue number15
DOIs
StatePublished - Dec 2012

Keywords

  • Antigen-presenting cells
  • Immune response
  • Leukocytes
  • Lipid-based nanoparticles
  • Liposomes
  • RNAi
  • T cells

ASJC Scopus subject areas

  • Pharmaceutical Science

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