Immunotherapy with porous silicon

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Biological applications of porous silicon (PSi) include, but are not limited to, delivery of drugs, imaging, and immune modulatory agents. Porous particles in defined sizes and shapes can be made from silicon wafers using a combination of photolithography and electrochemical etching. The resulting particles are biocompatible, degrade into nontoxic products, and are easily functionalized and loaded with cargo.With respect to immunotherapy applications, particles are functionalized with ligands, specifically pathogen-associated molecular patterns, that enable them to work with the immune system, activating antigen-presenting cells (APC) to initiate immune responses against foreign invaders and pathogenic cells.

Original languageEnglish (US)
Title of host publicationHandbook of Porous Silicon
Subtitle of host publicationSecond Edition
PublisherSpringer International Publishing
Pages1419-1432
Number of pages14
Volume2-2
ISBN (Electronic)9783319713816
ISBN (Print)9783319713793
DOIs
StatePublished - Jul 4 2018

Keywords

  • Adaptive immunity
  • Adjuvant
  • Antibody
  • Antigen
  • Cellular immunity
  • Cross presentation of antigen
  • Cytokine
  • Dendritic cells
  • Macrophages
  • Mimetics
  • Myeloid cells
  • Pathogen-associated molecular patterns
  • T cells
  • Toll-like receptor

ASJC Scopus subject areas

  • Engineering(all)
  • Materials Science(all)
  • Chemistry(all)
  • Physics and Astronomy(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Immunotherapy with porous silicon'. Together they form a unique fingerprint.

Cite this