Immunotherapy to reconstitute immunity to DNA viruses

Benedikt Gahn, Garrett Hunt, Cliona M. Rooney, Helen Heslop

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Defects in cytotoxic T-lymphocyte (CTL) function after hemopoietic stem cell transplantation (HSCT) are associated with an increased frequency and severity of viral diseases. Initial investigations of viral infections in immunosuppressed mice and subsequent clinical studies of cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in human stem cell transplant patients have suggested that adoptive transfer of virus-specific T cells may restore protective immunity and control established infections. Current efforts focus on optimizing adoptive immunotherapy approaches and developing strategies for generating T cells specific for multiple viruses to provide broader protection.

Original languageEnglish (US)
Pages (from-to)41-47
Number of pages7
JournalSeminars in hematology
Volume39
Issue number1
DOIs
StatePublished - 2002

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Immunotherapy to reconstitute immunity to DNA viruses'. Together they form a unique fingerprint.

Cite this