Immunotherapy to reconstitute immunity to DNA viruses

Benedikt Gahn, Garrett Hunt, Cliona M. Rooney, Helen Heslop

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Defects in cytotoxic T-lymphocyte (CTL) function after hemopoietic stem cell transplantation (HSCT) are associated with an increased frequency and severity of viral diseases. Initial investigations of viral infections in immunosuppressed mice and subsequent clinical studies of cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in human stem cell transplant patients have suggested that adoptive transfer of virus-specific T cells may restore protective immunity and control established infections. Current efforts focus on optimizing adoptive immunotherapy approaches and developing strategies for generating T cells specific for multiple viruses to provide broader protection.

Original languageEnglish (US)
Pages (from-to)41-47
Number of pages7
JournalSeminars in hematology
Issue number1
StatePublished - 2002

ASJC Scopus subject areas

  • Hematology


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