Immunotherapy to reconstitute immunity to DNA viruses

Benedikt Gahn; Garrett Hunt; Cliona M. Rooney; Helen Heslop

doi:10.1053/shem.2002.29252

Immunotherapy to reconstitute immunity to DNA viruses

Benedikt Gahn, Garrett Hunt, Cliona M. Rooney, Helen Heslop

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Defects in cytotoxic T-lymphocyte (CTL) function after hemopoietic stem cell transplantation (HSCT) are associated with an increased frequency and severity of viral diseases. Initial investigations of viral infections in immunosuppressed mice and subsequent clinical studies of cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in human stem cell transplant patients have suggested that adoptive transfer of virus-specific T cells may restore protective immunity and control established infections. Current efforts focus on optimizing adoptive immunotherapy approaches and developing strategies for generating T cells specific for multiple viruses to provide broader protection.

Original language	English (US)
Pages (from-to)	41-47
Number of pages	7
Journal	Seminars in hematology
Volume	39
Issue number	1
DOIs	https://doi.org/10.1053/shem.2002.29252
State	Published - 2002

ASJC Scopus subject areas

Hematology

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10.1053/shem.2002.29252

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abstract = "Defects in cytotoxic T-lymphocyte (CTL) function after hemopoietic stem cell transplantation (HSCT) are associated with an increased frequency and severity of viral diseases. Initial investigations of viral infections in immunosuppressed mice and subsequent clinical studies of cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in human stem cell transplant patients have suggested that adoptive transfer of virus-specific T cells may restore protective immunity and control established infections. Current efforts focus on optimizing adoptive immunotherapy approaches and developing strategies for generating T cells specific for multiple viruses to provide broader protection.",

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AU - Gahn, Benedikt

AU - Hunt, Garrett

AU - Rooney, Cliona M.

AU - Heslop, Helen

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AB - Defects in cytotoxic T-lymphocyte (CTL) function after hemopoietic stem cell transplantation (HSCT) are associated with an increased frequency and severity of viral diseases. Initial investigations of viral infections in immunosuppressed mice and subsequent clinical studies of cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in human stem cell transplant patients have suggested that adoptive transfer of virus-specific T cells may restore protective immunity and control established infections. Current efforts focus on optimizing adoptive immunotherapy approaches and developing strategies for generating T cells specific for multiple viruses to provide broader protection.

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JO - Seminars in hematology

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SN - 0037-1963

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ER -

Immunotherapy to reconstitute immunity to DNA viruses

Abstract

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