Immunotherapy of human cancers using gene modified T lymphocytes

Juan F. Vera, Malcolm K. Brenner, Gianpietro Dotti

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations


Adoptive T cell therapies can produce objective clinical responses in patients with hematologic and solid malignancies. Genetic manipulation of T lymphocytes has been proposed as a means of increasing the potency and range of this anti-tumor activity. We now review how coupling expression of transgenic receptors with countermeasures against potent tumor immune evasion strategies is proving highly effective in pre-clinical models and describe how these approaches are being evaluated in human subjects.

Original languageEnglish (US)
Pages (from-to)396-408
Number of pages13
JournalCurrent Gene Therapy
Issue number5
StatePublished - 2009

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Drug Discovery
  • Genetics(clinical)


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