Immunotherapy of human cancers using gene modified T lymphocytes

Juan F. Vera; Malcolm K. Brenner; Gianpietro Dotti

doi:10.2174/156652309789753338

Immunotherapy of human cancers using gene modified T lymphocytes

Juan F. Vera, Malcolm K. Brenner, Gianpietro Dotti

Research output: Contribution to journal › Review article › peer-review

26 Scopus citations

Abstract

Adoptive T cell therapies can produce objective clinical responses in patients with hematologic and solid malignancies. Genetic manipulation of T lymphocytes has been proposed as a means of increasing the potency and range of this anti-tumor activity. We now review how coupling expression of transgenic receptors with countermeasures against potent tumor immune evasion strategies is proving highly effective in pre-clinical models and describe how these approaches are being evaluated in human subjects.

Original language	English (US)
Pages (from-to)	396-408
Number of pages	13
Journal	Current Gene Therapy
Volume	9
Issue number	5
DOIs	https://doi.org/10.2174/156652309789753338
State	Published - 2009

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Genetics
Drug Discovery
Genetics(clinical)

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title = "Immunotherapy of human cancers using gene modified T lymphocytes",

abstract = "Adoptive T cell therapies can produce objective clinical responses in patients with hematologic and solid malignancies. Genetic manipulation of T lymphocytes has been proposed as a means of increasing the potency and range of this anti-tumor activity. We now review how coupling expression of transgenic receptors with countermeasures against potent tumor immune evasion strategies is proving highly effective in pre-clinical models and describe how these approaches are being evaluated in human subjects.",

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AB - Adoptive T cell therapies can produce objective clinical responses in patients with hematologic and solid malignancies. Genetic manipulation of T lymphocytes has been proposed as a means of increasing the potency and range of this anti-tumor activity. We now review how coupling expression of transgenic receptors with countermeasures against potent tumor immune evasion strategies is proving highly effective in pre-clinical models and describe how these approaches are being evaluated in human subjects.

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Immunotherapy of human cancers using gene modified T lymphocytes

Abstract

ASJC Scopus subject areas

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