Immunotherapy for neurological diseases

Pablo Villoslada; Beatriz Moreno; Ignacio Melero; Jose L. Pablos; Gianvito Martino; Antonio Uccelli; Xavier Montalban; Jesus Avila; Serge Rivest; Laia Acarin; Stanley Appel; Samia J. Khoury; Patrick McGeer; Isidro Ferrer; Mario Delgado; Jose Obeso; Michal Schwartz

doi:10.1016/j.clim.2008.04.003

Immunotherapy for neurological diseases

Pablo Villoslada, Beatriz Moreno, Ignacio Melero, Jose L. Pablos, Gianvito Martino, Antonio Uccelli, Xavier Montalban, Jesus Avila, Serge Rivest, Laia Acarin, Stanley Appel, Samia J. Khoury, Patrick McGeer, Isidro Ferrer, Mario Delgado, Jose Obeso, Michal Schwartz

Research output: Contribution to journal › Short survey › peer-review

44 Scopus citations

Abstract

The burden of neurological diseases in western societies has accentuated the need to develop effective therapies to stop the progression of chronic neurological diseases. Recent discoveries regarding the role of the immune system in brain damage coupled with the development of new technologies to manipulate the immune response make immunotherapies an attractive possibility to treat neurological diseases. The wide repertoire of immune responses and the possibility to engineer such responses, as well as their capacity to promote tissue repair, indicates that immunotherapy might offer benefits in the treatment of neurological diseases, similar to the benefits that are being associated with the treatment of cancer and autoimmune diseases. However, before applying such strategies to patients it is necessary to better understand the pathologies to be targeted, as well as how individual subjects may respond to immunotherapies, either in isolation or in combination. Due to the powerful effects of the immune system, one priority is to avoid tissue damage due to the activity of the immune system, particularly considering that the nervous system does not tolerate even the smallest amount of tissue damage.

Original language	English (US)
Pages (from-to)	294-305
Number of pages	12
Journal	Clinical Immunology
Volume	128
Issue number	3
DOIs	https://doi.org/10.1016/j.clim.2008.04.003
State	Published - Sep 2008

Keywords

Alzheimer disease
Amyotrophic lateral sclerosis
Cell therapy
Immunotherapy
Multiple sclerosis
Neurological diseases
Neuroprotection
Parkinson disease
Stem cells
Vaccination

ASJC Scopus subject areas

Immunology
Immunology and Allergy

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10.1016/j.clim.2008.04.003

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title = "Immunotherapy for neurological diseases",

abstract = "The burden of neurological diseases in western societies has accentuated the need to develop effective therapies to stop the progression of chronic neurological diseases. Recent discoveries regarding the role of the immune system in brain damage coupled with the development of new technologies to manipulate the immune response make immunotherapies an attractive possibility to treat neurological diseases. The wide repertoire of immune responses and the possibility to engineer such responses, as well as their capacity to promote tissue repair, indicates that immunotherapy might offer benefits in the treatment of neurological diseases, similar to the benefits that are being associated with the treatment of cancer and autoimmune diseases. However, before applying such strategies to patients it is necessary to better understand the pathologies to be targeted, as well as how individual subjects may respond to immunotherapies, either in isolation or in combination. Due to the powerful effects of the immune system, one priority is to avoid tissue damage due to the activity of the immune system, particularly considering that the nervous system does not tolerate even the smallest amount of tissue damage.",

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AU - Moreno, Beatriz

AU - Melero, Ignacio

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AU - Martino, Gianvito

AU - Uccelli, Antonio

AU - Montalban, Xavier

AU - Avila, Jesus

AU - Rivest, Serge

AU - Acarin, Laia

AU - Appel, Stanley

AU - Khoury, Samia J.

AU - McGeer, Patrick

AU - Ferrer, Isidro

AU - Delgado, Mario

AU - Obeso, Jose

AU - Schwartz, Michal

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AB - The burden of neurological diseases in western societies has accentuated the need to develop effective therapies to stop the progression of chronic neurological diseases. Recent discoveries regarding the role of the immune system in brain damage coupled with the development of new technologies to manipulate the immune response make immunotherapies an attractive possibility to treat neurological diseases. The wide repertoire of immune responses and the possibility to engineer such responses, as well as their capacity to promote tissue repair, indicates that immunotherapy might offer benefits in the treatment of neurological diseases, similar to the benefits that are being associated with the treatment of cancer and autoimmune diseases. However, before applying such strategies to patients it is necessary to better understand the pathologies to be targeted, as well as how individual subjects may respond to immunotherapies, either in isolation or in combination. Due to the powerful effects of the immune system, one priority is to avoid tissue damage due to the activity of the immune system, particularly considering that the nervous system does not tolerate even the smallest amount of tissue damage.

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KW - Amyotrophic lateral sclerosis

KW - Cell therapy

KW - Immunotherapy

KW - Multiple sclerosis

KW - Neurological diseases

KW - Neuroprotection

KW - Parkinson disease

KW - Stem cells

KW - Vaccination

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Immunotherapy for neurological diseases

Abstract

Keywords

ASJC Scopus subject areas

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