Immuntherapeutika gegen Kopf-Hals-Plattenepithelkarzinom-Stammzellen

Translated title of the contribution: Immunotherapeutics for head and neck squamous cell carcinoma stem cells

X. Qian, F. Leonard, Y. Wenhao, H. Sudhoff, T. K. Hoffmann, S. Ferrone, A. M. Kaufmann, A. E. Albers

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Cancer stem cell (CSC)-related therapy resistance has become a new obstacle to the successful application of cancer treatment and head and neck squamous cell carcinoma (HNSCC) is no exception to this finding. Head and neck squamous cell carcinoma is highly immune-suppressive, and recently the immune suppression and invasion of HNSCC-CSCs have been characterized. These characteristics have received research and clinical attention because they would enable the stratification of patients into specific cancer subtypes and, consequently, the establishment of new therapeutic approaches with improved efficacy. This review discusses the feasibility of CSC-targeted strategies and their incorporation with nanotechnology to improve the efficacy of cancer immunotherapy.

Translated title of the contributionImmunotherapeutics for head and neck squamous cell carcinoma stem cells
Original languageGerman
Pages (from-to)94-99
Number of pages6
JournalHNO
Volume68
Issue number2
DOIs
StatePublished - Feb 1 2020

Keywords

  • Cancer nanomedicine
  • Cancer stem cell
  • Cancer vaccine
  • Immunotherapy
  • Nanotechnology

ASJC Scopus subject areas

  • Otorhinolaryngology

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