Immunotherapeutic Transport Oncophysics: Space, Time, and Immune Activation in Cancer

Sara Nizzero; Haifa Shen; Mauro Ferrari; Bruna Corradetti

doi:10.1016/j.trecan.2019.11.008

Immunotherapeutic Transport Oncophysics: Space, Time, and Immune Activation in Cancer

Sara Nizzero, Haifa Shen, Mauro Ferrari, Bruna Corradetti

Research output: Contribution to journal › Review article

2 Scopus citations

Abstract

Immuno-oncology has gained momentum thanks to the success of strategies aimed at enhancing immune-mediated antitumor response. The field of immunotherapeutic transport oncophysics investigates the physical processes that drive cancer immunotherapies. This review discusses three main aspects that determine the outcome of an immunotherapy-based treatment from a physical point of view; (i) space, the distribution of cancer and immune cells within tumor masses, (ii) time, the temporal dynamic of immune response against tumors, and (iii) activity, the ability of immune cell populations to suppress cancer. Upon introducing these topics with examples from the literature, we investigate in detail two cases where the interplay between space, time, and activation variables determines immune response: nanodendritic cell vaccines and immunosuppression in ovarian cancer.

Original language	English (US)
Pages (from-to)	40-48
Number of pages	9
Journal	Trends in Cancer
Volume	6
Issue number	1
DOIs	https://doi.org/10.1016/j.trecan.2019.11.008
State	Published - Jan 1 2020

Keywords

cancer
immuno-oncology
immunotherapy
physics of cancer
transport oncophysics

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.1016/j.trecan.2019.11.008

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abstract = "Immuno-oncology has gained momentum thanks to the success of strategies aimed at enhancing immune-mediated antitumor response. The field of immunotherapeutic transport oncophysics investigates the physical processes that drive cancer immunotherapies. This review discusses three main aspects that determine the outcome of an immunotherapy-based treatment from a physical point of view; (i) space, the distribution of cancer and immune cells within tumor masses, (ii) time, the temporal dynamic of immune response against tumors, and (iii) activity, the ability of immune cell populations to suppress cancer. Upon introducing these topics with examples from the literature, we investigate in detail two cases where the interplay between space, time, and activation variables determines immune response: nanodendritic cell vaccines and immunosuppression in ovarian cancer.",

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