@article{fdf3c13e7bdd440397ff336827b5082d,
title = "Immunotherapeutic Transport Oncophysics: Space, Time, and Immune Activation in Cancer",
abstract = "Immuno-oncology has gained momentum thanks to the success of strategies aimed at enhancing immune-mediated antitumor response. The field of immunotherapeutic transport oncophysics investigates the physical processes that drive cancer immunotherapies. This review discusses three main aspects that determine the outcome of an immunotherapy-based treatment from a physical point of view; (i) space, the distribution of cancer and immune cells within tumor masses, (ii) time, the temporal dynamic of immune response against tumors, and (iii) activity, the ability of immune cell populations to suppress cancer. Upon introducing these topics with examples from the literature, we investigate in detail two cases where the interplay between space, time, and activation variables determines immune response: nanodendritic cell vaccines and immunosuppression in ovarian cancer.",
keywords = "cancer, immuno-oncology, immunotherapy, physics of cancer, transport oncophysics",
author = "Sara Nizzero and Haifa Shen and Mauro Ferrari and Bruna Corradetti",
note = "Funding Information: B.C. acknowledges support through the S{\^e}r Cymru II scheme, funded by European Union{\textquoteright}s Horizon 2020 research and innovation programme under the Marie Sk{\l}odowska-Curie grant agreement No 663830 and the Welsh European Funding Office (WEFO) under the European Regional Development Fund (ERDF). The authors also acknowledge support from National Institutes of Health (NIH) grant U54CA210181 . The authors further acknowledge Matthew G. Landry for support in designing and producing the graphical elements in the manuscript. Funding Information: B.C. acknowledges support through the S{\^e}r Cymru II scheme, funded by European Union's Horizon 2020 research and innovation programme under the Marie Sk{\l}odowska-Curie grant agreement No 663830 and the Welsh European Funding Office (WEFO) under the European Regional Development Fund (ERDF). The authors also acknowledge support from National Institutes of Health (NIH) grant U54CA210181. The authors further acknowledge Matthew G. Landry for support in designing and producing the graphical elements in the manuscript. Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2020",
month = jan,
doi = "10.1016/j.trecan.2019.11.008",
language = "English (US)",
volume = "6",
pages = "40--48",
journal = "Trends in Cancer",
issn = "2405-8033",
publisher = "Cell Press",
number = "1",
}