Immunotherapeutic Transport Oncophysics: Space, Time, and Immune Activation in Cancer

Research output: Contribution to journalReview article

Sara Nizzero, Haifa Shen, Mauro Ferrari, Bruna Corradetti

Immuno-oncology has gained momentum thanks to the success of strategies aimed at enhancing immune-mediated antitumor response. The field of immunotherapeutic transport oncophysics investigates the physical processes that drive cancer immunotherapies. This review discusses three main aspects that determine the outcome of an immunotherapy-based treatment from a physical point of view; (i) space, the distribution of cancer and immune cells within tumor masses, (ii) time, the temporal dynamic of immune response against tumors, and (iii) activity, the ability of immune cell populations to suppress cancer. Upon introducing these topics with examples from the literature, we investigate in detail two cases where the interplay between space, time, and activation variables determines immune response: nanodendritic cell vaccines and immunosuppression in ovarian cancer.

Original languageEnglish (US)
Pages (from-to)40-48
Number of pages9
JournalTrends in Cancer
Volume6
Issue number1
DOIs
StatePublished - Jan 1 2020

PMID: 31952780

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Immunotherapeutic Transport Oncophysics : Space, Time, and Immune Activation in Cancer. / Nizzero, Sara; Shen, Haifa; Ferrari, Mauro; Corradetti, Bruna.

In: Trends in Cancer, Vol. 6, No. 1, 01.01.2020, p. 40-48.

Research output: Contribution to journalReview article

Harvard

Nizzero, S, Shen, H, Ferrari, M & Corradetti, B 2020, 'Immunotherapeutic Transport Oncophysics: Space, Time, and Immune Activation in Cancer' Trends in Cancer, vol. 6, no. 1, pp. 40-48. https://doi.org/10.1016/j.trecan.2019.11.008

APA

Nizzero, S., Shen, H., Ferrari, M., & Corradetti, B. (2020). Immunotherapeutic Transport Oncophysics: Space, Time, and Immune Activation in Cancer. Trends in Cancer, 6(1), 40-48. https://doi.org/10.1016/j.trecan.2019.11.008

Vancouver

Nizzero S, Shen H, Ferrari M, Corradetti B. Immunotherapeutic Transport Oncophysics: Space, Time, and Immune Activation in Cancer. Trends in Cancer. 2020 Jan 1;6(1):40-48. https://doi.org/10.1016/j.trecan.2019.11.008

Author

Nizzero, Sara ; Shen, Haifa ; Ferrari, Mauro ; Corradetti, Bruna. / Immunotherapeutic Transport Oncophysics : Space, Time, and Immune Activation in Cancer. In: Trends in Cancer. 2020 ; Vol. 6, No. 1. pp. 40-48.

BibTeX

@article{fdf3c13e7bdd440397ff336827b5082d,
title = "Immunotherapeutic Transport Oncophysics: Space, Time, and Immune Activation in Cancer",
abstract = "Immuno-oncology has gained momentum thanks to the success of strategies aimed at enhancing immune-mediated antitumor response. The field of immunotherapeutic transport oncophysics investigates the physical processes that drive cancer immunotherapies. This review discusses three main aspects that determine the outcome of an immunotherapy-based treatment from a physical point of view; (i) space, the distribution of cancer and immune cells within tumor masses, (ii) time, the temporal dynamic of immune response against tumors, and (iii) activity, the ability of immune cell populations to suppress cancer. Upon introducing these topics with examples from the literature, we investigate in detail two cases where the interplay between space, time, and activation variables determines immune response: nanodendritic cell vaccines and immunosuppression in ovarian cancer.",
keywords = "cancer, immuno-oncology, immunotherapy, physics of cancer, transport oncophysics",
author = "Sara Nizzero and Haifa Shen and Mauro Ferrari and Bruna Corradetti",
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language = "English (US)",
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journal = "Trends in Cancer",
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RIS

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T1 - Immunotherapeutic Transport Oncophysics

T2 - Trends in Cancer

AU - Nizzero, Sara

AU - Shen, Haifa

AU - Ferrari, Mauro

AU - Corradetti, Bruna

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Immuno-oncology has gained momentum thanks to the success of strategies aimed at enhancing immune-mediated antitumor response. The field of immunotherapeutic transport oncophysics investigates the physical processes that drive cancer immunotherapies. This review discusses three main aspects that determine the outcome of an immunotherapy-based treatment from a physical point of view; (i) space, the distribution of cancer and immune cells within tumor masses, (ii) time, the temporal dynamic of immune response against tumors, and (iii) activity, the ability of immune cell populations to suppress cancer. Upon introducing these topics with examples from the literature, we investigate in detail two cases where the interplay between space, time, and activation variables determines immune response: nanodendritic cell vaccines and immunosuppression in ovarian cancer.

AB - Immuno-oncology has gained momentum thanks to the success of strategies aimed at enhancing immune-mediated antitumor response. The field of immunotherapeutic transport oncophysics investigates the physical processes that drive cancer immunotherapies. This review discusses three main aspects that determine the outcome of an immunotherapy-based treatment from a physical point of view; (i) space, the distribution of cancer and immune cells within tumor masses, (ii) time, the temporal dynamic of immune response against tumors, and (iii) activity, the ability of immune cell populations to suppress cancer. Upon introducing these topics with examples from the literature, we investigate in detail two cases where the interplay between space, time, and activation variables determines immune response: nanodendritic cell vaccines and immunosuppression in ovarian cancer.

KW - cancer

KW - immuno-oncology

KW - immunotherapy

KW - physics of cancer

KW - transport oncophysics

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UR - http://www.scopus.com/inward/citedby.url?scp=85077141069&partnerID=8YFLogxK

U2 - 10.1016/j.trecan.2019.11.008

DO - 10.1016/j.trecan.2019.11.008

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JO - Trends in Cancer

JF - Trends in Cancer

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IS - 1

ER -

ID: 57309130