Immunosuppressive agents

B. D. Kahan; R. Ghobrial

doi:10.1016/s0039-6109(16)46432-7

Immunosuppressive agents

B. D. Kahan, R. Ghobrial

Research output: Contribution to journal › Review article › peer-review

39 Scopus citations

Abstract

The present success of organ transplantation is largely due to advances in immunosuppressive therapy. Progress has been made from a cytotoxic strategy associated with a high morbidity rate to a strategy that seeks to alter the activity of cells that regulate the immune response, in order to selectively dampen antidonor responses. This article presents a comprehensive review of the clinical matrix of immunosuppressive agents, which includes various combinations of pharmacologic agents tailored to minimize toxicity and to enhance efficacy.

Original language	English (US)
Pages (from-to)	1029-1054
Number of pages	26
Journal	Surgical Clinics of North America
Volume	74
Issue number	5
DOIs	https://doi.org/10.1016/s0039-6109(16)46432-7
State	Published - 1994

ASJC Scopus subject areas

Surgery

Divisions

Abdominal Transplant

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10.1016/s0039-6109(16)46432-7

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@article{4e3705009e31448f939654eeb61cf0eb,

title = "Immunosuppressive agents",

abstract = "The present success of organ transplantation is largely due to advances in immunosuppressive therapy. Progress has been made from a cytotoxic strategy associated with a high morbidity rate to a strategy that seeks to alter the activity of cells that regulate the immune response, in order to selectively dampen antidonor responses. This article presents a comprehensive review of the clinical matrix of immunosuppressive agents, which includes various combinations of pharmacologic agents tailored to minimize toxicity and to enhance efficacy.",

author = "Kahan, \{B. D.\} and R. Ghobrial",

note = "Funding Information: 'This is publication number 1084 . The work reported here was supported by National Institutes of Health Program Project Grant A1 07007 and a Program Project Grant from the National Heart and Lung Institute. HL 16411. ' Recipient of an Established Investigatorship No . 73-144 from the American Heart Association. 'Cecil H . and Ida M . Green Investigator in Medical Research. Scripps Clinic and Research Foundation . Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "1994",

doi = "10.1016/s0039-6109(16)46432-7",

language = "English (US)",

volume = "74",

pages = "1029--1054",

journal = "Surgical Clinics of North America",

issn = "0039-6109",

publisher = "W.B. Saunders",

number = "5",

}

TY - JOUR

T1 - Immunosuppressive agents

AU - Kahan, B. D.

AU - Ghobrial, R.

N1 - Funding Information: 'This is publication number 1084 . The work reported here was supported by National Institutes of Health Program Project Grant A1 07007 and a Program Project Grant from the National Heart and Lung Institute. HL 16411. ' Recipient of an Established Investigatorship No . 73-144 from the American Heart Association. 'Cecil H . and Ida M . Green Investigator in Medical Research. Scripps Clinic and Research Foundation . Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 1994

Y1 - 1994

N2 - The present success of organ transplantation is largely due to advances in immunosuppressive therapy. Progress has been made from a cytotoxic strategy associated with a high morbidity rate to a strategy that seeks to alter the activity of cells that regulate the immune response, in order to selectively dampen antidonor responses. This article presents a comprehensive review of the clinical matrix of immunosuppressive agents, which includes various combinations of pharmacologic agents tailored to minimize toxicity and to enhance efficacy.

AB - The present success of organ transplantation is largely due to advances in immunosuppressive therapy. Progress has been made from a cytotoxic strategy associated with a high morbidity rate to a strategy that seeks to alter the activity of cells that regulate the immune response, in order to selectively dampen antidonor responses. This article presents a comprehensive review of the clinical matrix of immunosuppressive agents, which includes various combinations of pharmacologic agents tailored to minimize toxicity and to enhance efficacy.

UR - https://www.scopus.com/pages/publications/0028126613

UR - https://www.scopus.com/inward/citedby.url?scp=0028126613&partnerID=8YFLogxK

U2 - 10.1016/s0039-6109(16)46432-7

DO - 10.1016/s0039-6109(16)46432-7

M3 - Review article

C2 - 7940060

AN - SCOPUS:0028126613

SN - 0039-6109

VL - 74

SP - 1029

EP - 1054

JO - Surgical Clinics of North America

JF - Surgical Clinics of North America

IS - 5

ER -

Immunosuppressive agents

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